IUBMB Enzyme Nomenclature


Accepted name: DNA topoisomerase (ATP-hydrolysing)

Reaction: ATP-dependent breakage, passage and rejoining of double-stranded DNA

Other name(s): type II DNA topoisomerase; DNA-gyrase; deoxyribonucleate topoisomerase; deoxyribonucleic topoisomerase; topoisomerase; DNA topoisomerase II

Systematic name: DNA topoisomerase (ATP-hydrolysing)

Comments: The enzyme can introduce negative superhelical turns into double-stranded circular DNA. One unit has nicking-closing activity, and another catalyses super-twisting and hydrolysis of ATP (cf. EC DNA topoisomerase).

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Gellert, M. DNA topoisomerases. Annu. Rev. Biochem. 50 (1981) 879-910. [PMID: 6267993]

[EC created 1984 as, transferred 2018 to EC]

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