IUBMB Enzyme Nomenclature


Accepted name: alanine—tRNA ligase

Reaction: ATP + L-alanine + tRNAAla = AMP + diphosphate + L-alanyl-tRNAAla

Other name(s): alanyl-tRNA synthetase; alanyl-transfer ribonucleate synthetase; alanyl-transfer RNA synthetase; alanyl-transfer ribonucleic acid synthetase; alanine-transfer RNA ligase; alanine transfer RNA synthetase; alanine tRNA synthetase; alanine translase; alanyl-transfer ribonucleate synthase; AlaRS; Ala-tRNA synthetase

Systematic name: L-alanine:tRNAAla ligase (AMP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9031-71-4


1. Holley, R.W. and Goldstein, J. An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. J. Biol. Chem. 234 (1959) 1765-1768.

2. Webster, G.C. Isolation of an alanine-activating enzyme from pig liver. Biochim. Biophys. Acta 49 (1961) 141-152.

[EC created 1961]

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