IUBMB Enzyme Nomenclature


Accepted name: acetate—CoA ligase (ADP-forming)

Reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA

Other name(s): acetyl-CoA synthetase (ADP-forming); acetyl coenzyme A synthetase (adenosine diphosphate-forming); acetate thiokinase

Systematic name: acetate:CoA ligase (ADP-forming)

Comments: Also acts on propanoate and, very slowly, on butanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 62009-85-2


1. Reeves, R.E., Warren, L.G., Susskind, B. and Lo, H.-S. An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase. J. Biol. Chem. 252 (1977) 726-731. [PMID: 13076]

[EC created 1978]

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