IUBMB Enzyme Nomenclature


Accepted name: arachidonate—CoA ligase

Reaction: ATP + arachidonate + CoA = AMP + diphosphate + arachidonoyl-CoA

arachidonate: (all-Z)-icosa-5,8,11,14-tetraenoate

Other name(s): arachidonoyl-CoA synthetase

Systematic name: arachidonate:CoA ligase (AMP-forming)

Comments: Not identical with EC long-chain-fatty-acid—CoA ligase. Icosa-8,11,14-trienoate, but not the other long-chain fatty acids, can act in place of arachidonate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 82047-87-8


1. Wilson, D.B., Prescott, S.M. and Majerus, P.W. Discovery of an arachidonoyl coenzyme A synthetase in human platelets. J. Biol. Chem. 257 (1982) 3510-3515. [PMID: 7061494]

[EC created 1984]

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