IUBMB Enzyme Nomenclature


Accepted name: citrate—CoA ligase

Reaction: ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA

citrate: 2-hydroxypropane-1,2,3-tricarboxylate

Other name(s): citryl-CoA synthetase; citrate:CoA ligase; citrate thiokinase

Systematic name: citrate:CoA ligase (ADP-forming)

Comments: The enzyme is a component of EC ATP citrate synthase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 856428-87-0


1. Lill, U., Schreil, A. and Eggerer, H. Isolation of enzymically active fragments formed by limited proteolysis of ATP citrate lyase. Eur. J. Biochem. 125 (1982) 645-650. [PMID: 6749502]

2. Aoshima, M., Ishii, M. and Igarashi, Y. A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6. Mol. Microbiol. 52, (2004) 751-761. [PMID: 15101981]

[EC created 1986]

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