IUBMB Enzyme Nomenclature


Accepted name: dicarboxylate—CoA ligase

Reaction: ATP + an α,ω-dicarboxylate + CoA = AMP + diphosphate + an ω-carboxyacyl-CoA

Other name(s): carboxylyl-CoA synthetase; dicarboxylyl-CoA synthetase

Systematic name: ω-dicarboxylate:CoA ligase (AMP-forming)

Comments: Acts on dicarboxylic acids of chain length C5 to C16; the best substrate is dodecanedioic acid.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 99332-77-1


1. Vamecq, J., de Hoffmann, E. and van Hoof, F. The microsomal dicarboxylyl-CoA synthetase. Biochem. J. 230 (1985) 683-693. [PMID: 4062873]

[EC created 1989, modified 2011]

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