IUBMB Enzyme Nomenclature


Accepted name: benzoate—CoA ligase

Reaction: ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA

For diagram of reaction click here.

Other name(s): benzoate—coenzyme A ligase; benzoyl-coenzyme A synthetase; benzoyl CoA synthetase (AMP forming)

Systematic name: benzoate:CoA ligase (AMP-forming)

Comments: Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on the corresponding chlorobenzoates.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 95329-17-2


1. Hutber, G.N. and Ribbons, D.W. Involvement of coenzyme-A esters in the metabolism of benzoate and cyclohexanecarboxylate by Rhodopseudomonas palustris. J. Gen. Microbiol. 129 (1983) 2413-2420.

2. Schennen, U., Braun, K. and Knackmuss, H.-J. Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading, denitrifying bacteria. J. Bacteriol. 161 (1985) 321-325. [PMID: 2857161]

[EC created 1989]

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