IUBMB Enzyme Nomenclature


Accepted name: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase

Reaction: ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA

For diagram of reaction click here.

Other name(s): NcsB2

Systematic name: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate:CoA ligase

Comments: The enzyme from the bacterium Streptomyces carzinostaticus is involved in the attachment of the 2-hydroxy-7-methoxy-5-methyl-1-naphthoate moiety of the antibiotic neocarzinostatin. In vitro the enzyme also catalyses the activation of other 1-naphthoic acid analogues, e.g. 2-hydroxy-5-methyl-1-naphthoate or 2,7-dihydroxy-5-methyl-1-naphthoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Cooke, H.A., Zhang, J., Griffin, M.A., Nonaka, K., Van Lanen, S.G., Shen, B. and Bruner, S.D. Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J. Am. Chem. Soc. 129 (2007) 7728-7729. [PMID: 17539640]

[EC created 2014]

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