IUBMB Enzyme Nomenclature


Accepted name: 4-hydroxybutyrate—CoA ligase (ADP-forming)

Reaction: ATP + 4-hydroxybutanoate + CoA = ADP + phosphate + 4-hydroxybutanoyl-CoA

For diagram of reaction click here

Other name(s): Nmar_0206 (locus name)

Systematic name: 4-hydroxybutanoate:CoA ligase (ADP-forming)

Comments: The enzyme, characterized from the marine ammonia-oxidizing archaeon Nitrosopumilus maritimus, participates in a variant of the 3-hydroxypropanoate/4-hydroxybutanate CO2 fixation cycle. cf. EC, 4-hydroxybutyrate—CoA ligase (AMP-forming).

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:


1. Konneke, M., Schubert, D.M., Brown, P.C., Hugler, M., Standfest, S., Schwander, T., Schada von Borzyskowski, L., Erb, T.J., Stahl, D.A. and Berg, I.A. Ammonia-oxidizing archaea use the most energy-efficient aerobic pathway for CO2 fixation. Proc. Natl Acad. Sci. USA 111 (2014) 8239-8244. [PMID: 24843170]

[EC created 2019]

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