IUBMB Enzyme Nomenclature


Accepted name: isophthalate—CoA ligase

Reaction: ATP + isophthalate + CoA = AMP + diphosphate + isophthalyl-CoA

Other name(s): IPCL

Systematic name: isophthalate:CoA ligase (AMP-forming)

Comments: The enzyme, characterized from the bacterium Syntrophorhabdus aromaticivorans, catalyses the first step in an anaerobic isophthalate degradation pathway.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Junghare, M., Spiteller, D. and Schink, B. Anaerobic degradation of xenobiotic isophthalate by the fermenting bacterium Syntrophorhabdus aromaticivorans. ISME J. 13 (2019) 1252-1268. [PMID: 30647456]

[EC created 2019]

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