IUBMB Enzyme Nomenclature


Accepted name: salicylate—CoA ligase

Reaction: ATP + salicylate + CoA = AMP + diphosphate + salicyl-CoA (overall reaction)
(1a) ATP + salicylate = diphosphate + (salicyl)adenylate
(1b) (salicyl)adenylate + CoA = AMP + salicyl-CoA

Other name(s): sdgA (gene name)

Systematic name: salicylate:CoA ligase (AMP-forming)

Comments: The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (salicyl)adenylate, followed by the transfer of the activated compound to coenzyme A.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc CAS registry number:


1. Bonting, C.F. and Fuchs, G. Anaerobic metabolism of 2-hydroxybenzoic acid (salicylic acid) by a denitrifying bacterium. Arch. Microbiol. 165 (1996) 402-408. [PMID: 8661934]

2. Ishiyama, D., Vujaklija, D. and Davies, J. Novel pathway of salicylate degradation by Streptomyces sp. strain WA46. Appl. Environ. Microbiol. 70 (2004) 1297-1306. [PMID: 15006746]

[EC created 2020]

Return to EC 6.2.1 home page
Return to EC 6.2 home page
Return to EC 6 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page