IUBMB Enzyme Nomenclature


Accepted name: L-tryptophan—[L-tryptophyl-carrier protein] ligase

Reaction: ATP + L-tryptophan + holo-[L-tryptophyl-carrier protein] = AMP + diphosphate + -L-tryptophyl-[L-tryptophyl-carrier protein] (overall reaction)
(1a) ATP + tryptophan = diphosphate + (L-tryptophyl)adenylate
(1b) (L-tryptophyl)adenylate + holo-[L-tryptophyl-carrier protein] = AMP + L-tryptophyl-[L-tryptophyl-carrier protein]

Other name(s): ecm13 (gene name); swb11 (gene name)

Systematic name: L-tryptophan:[L-tryptophyl-carrier protein] ligase (AMP-forming)

Comments: The adenylation domain of the enzyme catalyses the activation of L-tryptophan to (L-tryptophyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein, or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Zhang, C., Kong, L., Liu, Q., Lei, X., Zhu, T., Yin, J., Lin, B., Deng, Z. and You, D. In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan. PLoS One 8 (2013) e56772. [PMID: 23437232]

[EC created 2021]

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