IUBMB Enzyme Nomenclature


Accepted name: aspartate—ammonia ligase

Reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine

Other name(s): asparagine synthetase; L-asparagine synthetase

Systematic name: L-aspartate:ammonia ligase (AMP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9023-69-2


1. Ravel, J.M., Norton, S.J., Humphreys, J.S. and Shive, W. Asparagine biosynthesis in Lactobacillus arabinosus and its control by asparagine through enzyme inhibition and repression. J. Biol. Chem. 237 (1962) 2845-2849.

2. Webster, G.C. and Varner, J.E. Aspartate metabolism and asparagine synthesis in plant systems. J. Biol. Chem. 215 (1955) 91-99.

[EC created 1961]

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