IUBMB Enzyme Nomenclature


Accepted name: γ-glutamylanilide synthase

Reaction: ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine

Glossary: γ-glutamylanilide = N5-phenyl-L-glutamine

Other name(s): atdA1 (gene name); tdnQ (gene name); dcaQ (gene name)

Systematic name: L-glutamate:aniline ligase (ADP-forming)

Comments: Requires Mg2+. The enzyme, characterized from the bacterium Acinetobacter sp. YAA, catalyses the first step in the degradation of aniline. It can also accept chlorinated and methylated forms of aniline, preferrably in the o- and p-positions.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Takeo, M., Ohara, A., Sakae, S., Okamoto, Y., Kitamura, C., Kato, D. and Negoro, S. Function of a glutamine synthetase-like protein in bacterial aniline oxidation via γ-glutamylanilide. J. Bacteriol. 195 (2013) 4406-4414. [PMID: 23893114]

[EC created 2014]

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