IUBMB Enzyme Nomenclature


Accepted name: coenzyme γ-F420-2:α-L-glutamate ligase

Reaction: ATP + coenzyme γ-F420-2 + L-glutamate = ADP + phosphate + coenzyme α-F420-3

For diagram of reaction, click here

Other name(s): MJ1001; CofF protein; γ-F420-2:α-L-glutamate ligase

Systematic name: L-glutamate:coenzyme γ-F420-2 (ADP-forming)

Comments: The enzyme caps the γ-glutamyl tail of the hydride carrier coenzyme F420 [1].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Li, H., Xu, H., Graham, D.E. and White, R.H. Glutathione synthetase homologs encode α-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses. Proc. Natl. Acad. Sci. USA 100 (2003) 9785-9790. [PMID: 12909715]

[EC created 2010]

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