IUBMB Enzyme Nomenclature


Accepted name: tetrahydrosarcinapterin synthase

Reaction: ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin

For diagram of reaction click here.

Other name(s): H4MPT:α-L-glutamate ligase; MJ0620; MptN protein

Systematic name: tetrahydromethanopterin:α-L-glutamate ligase (ADP-forming)

Comments: This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].

Links to other databases: BRENDA, EXPASY, KEGG, CAS registry number:


1. Li, H., Xu, H., Graham, D.E. and White, R.H. Glutathione synthetase homologs encode α-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses. Proc. Natl. Acad. Sci. USA 100 (2003) 9785-9790. [PMID: 12909715]

[EC created 2010]

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