Accepted name: UDP-2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactose:2-oxoglutarate ligase
Reaction: ATP + UDP-2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactose + 2-oxoglutarate = ADP + phosphate + UDP-yelosamine
Glossary: UDP-yelosamine = UDP-N-acetyl-D-fucosamine-4N-(2)-oxoglutarate = UDP-D-FucNAc-4N-(2)-oxoglutarate
Other name(s): Pyl
Systematic name: UDP-2-acetamido-4-amino-2,4,6-trideoxy-α-D-galactose:2-oxoglutarate ligase (ADP-forming)
Comments: The enzyme, discovered in the bacterium Bacillus cereus ATCC 14579, produces the unusual nucleotide sugar UDP-yelosamine, which is incorporated into the capsular polysaccharide of this organism.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Hwang, S., Li, Z., Bar-Peled, Y., Aronov, A., Ericson, J. and Bar-Peled, M. The biosynthesis of UDP-D-FucNAc-4N-2-oxoglutarate (UDP-Yelosamine) in Bacillus cereus ATCC 14579: Pat and Pyl, an aminotransferase and an ATP-dependent Grasp protein that ligates 2-oxoglutarate to UDP-4-amino-sugars. J. Biol. Chem. 289 (2014) 35620-35632. [PMID: 25368324]