IUBMB Enzyme Nomenclature


Accepted name: biotin—[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase

Reaction: ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)]

Other name(s): biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase; biotin-propionyl coenzyme A carboxylase synthetase; propionyl coenzyme A holocarboxylase synthetase

Systematic name: biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37318-67-5


1. Siegel, L., Foote, J.L. and Coon, M.J. The enzymatic synthesis of propionyl coenzyme A holocarboxylase from d-biotinyl 5'-adenylate and the apocarboxylase. J. Biol. Chem. 240 (1965) 1025-1031.

[EC created 1972]

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