IUBMB Enzyme Nomenclature


Accepted name: 7-cyano-7-deazaguanine synthase

Reaction: 7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O

For diagram of reaction click here.

Glossary: preQ0 = 7-cyano-7-carbaguanine = 7-cyano-7-deazaguanine
7-carboxy-7-carbaguanine = 7-carboxy-7-deazaguanine

Other name(s): preQ0 synthase; 7-cyano-7-carbaguanine synthase; queC (gene name)

Systematic name: 7-carboxy-7-carbaguanine:ammonia ligase (ADP-forming)

Comments: Binds Zn2+. The reaction is part of the biosynthesis pathway of queuosine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. McCarty, R.M., Somogyi, A., Lin, G., Jacobsen, N.E. and Bandarian, V. The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of preQ0 from guanosine 5'-triphosphate in four steps. Biochemistry 48 (2009) 3847-3852. [PMID: 19354300]

2. Cicmil, N. and Huang, R.H. Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis. Proteins 72 (2008) 1084-1088. [PMID: 18491386]

[EC created 2012]

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