IUBMB Enzyme Nomenclature


Accepted name: adenylosuccinate synthase

Reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP

For diagram click here.

Other name(s): IMP—aspartate ligase; adenylosuccinate synthetase; succinoadenylic kinosynthetase; succino-AMP synthetase

Systematic name: IMP:L-aspartate ligase (GDP-forming)

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9023-57-8


1. Davey, C.L. Synthesis of adenylosuccinic acid in preparations of mammalian skeletal muscle. Nature 183 (1959) 995-996.

2. Lieberman, I. Enzymatic synthesis of adenosine-5'-phosphate from inosine-5'-phosphate. J. Biol. Chem. 223 (1956) 327-339.

3. Yefimochkina, E.F. and Braunstein, A.E. The amination of inosinic acid to adenylic acid in muscle extracts. Arch. Biochem. Biophys. 83 (1959) 350-352.

[EC created 1961]

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