IUBMB Enzyme Nomenclature


Accepted name: cyclic 2,3-diphosphoglycerate synthase

Reaction: ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate

Other name(s): cpgS (gene name)

Systematic name: (2R)-2,3-bisphosphoglycerate ligase (cyclizing)

Comments: The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Lehmacher, A., Vogt, A.B. and Hensel, R. Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus. FEBS Lett. 272 (1990) 94-98. [PMID: 2226838]

2. Matussek, K., Moritz, P., Brunner, N., Eckerskorn, C. and Hensel, R. Cloning, sequencing, and expression of the gene encoding cyclic 2,3-diphosphoglycerate synthetase, the key enzyme of cyclic 2,3-diphosphoglycerate metabolism in Methanothermus fervidus. J. Bacteriol. 180 (1998) 5997-6004. [PMID: 9811660]

[EC created 2020]

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