IUBMB Enzyme Nomenclature


Accepted name: 3-amino-2-hydroxy-4-methoxybenzoate diazotase

Reaction: ATP + 3-amino-2-hydroxy-4-methoxybenzoate + nitrite = AMP + diphosphate + cremeomycin + H2O

For diagram of reaction, click here

Glossary: cremeomycin = 6-carboxy-2-diazonio-3-methoxyphenolate

Other name(s): creM (gene name)

Systematic name: 3-amino-2-hydroxy-4-methoxybenzoate:nitrite ligase (AMP-forming)

Comments: The enzyme, characterized from Streptomyces cremeus, catalyses the last step in the biosynthesis of the ortho-diazoquinone cremeomycin.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Waldman, A.J. and Balskus, E.P. Discovery of a diazo-forming enzyme in cremeomycin biosynthesis. J. Org. Chem. 83 (2018) 7539-7546. [PMID: 29771512]

[EC created 2021]

Return to EC 6.7.1 home page
Return to EC 6.7 home page
Return to EC 6 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page