Contents EC 6.1.1.1 - EC 6.5.1.4

EC 6.1.1 Ligases Forming Aminoacyl-tRNA and Related Compounds

EC 6.1.1.1 tyrosine—tRNA ligase
EC 6.1.1.2 tryptophan—tRNA ligase
EC 6.1.1.3 threonine—tRNA ligase
EC 6.1.1.4 leucine—tRNA ligase
EC 6.1.1.5 isoleucine—tRNA ligase
EC 6.1.1.6 lysine—tRNA ligase
EC 6.1.1.7 alanine—tRNA ligase
EC 6.1.1.8 deleted
EC 6.1.1.9 valine—tRNA ligase
EC 6.1.1.10 methionine—tRNA ligase
EC 6.1.1.11 serine—tRNA ligase
EC 6.1.1.12 aspartate—tRNA ligase
EC 6.1.1.13 D-alanine—poly(phosphoribitol) ligase
EC 6.1.1.14 glycine—tRNA ligase
EC 6.1.1.15 proline—tRNA ligase
EC 6.1.1.16 cysteine—tRNA ligase
EC 6.1.1.17 glutamate—tRNA ligase
EC 6.1.1.18 glutamine—tRNA ligase
EC 6.1.1.19 arginine—tRNA ligase
EC 6.1.1.20 phenylalanine—tRNA ligase
EC 6.1.1.21 histidine—tRNA ligase
EC 6.1.1.22 asparagine—tRNA ligase
EC 6.1.1.23 aspartate—tRNA^Asn ligase
EC 6.1.1.24 glutamate—tRNA^Gln ligase
EC 6.1.1.25 deleted
EC 6.1.1.26 pyrrolysine—tRNA^Pyl ligase
EC 6.1.1.27 O-phosphoserine—tRNA ligase
EC 6.1.1.28 deleted

EC 6.1.2 Acid—Alcohol Ligases (ester synthases)

EC 6.1.2.1 D-alanine—(R)-lactate ligase
EC 6.1.2.2 nebramycin 5' synthase

EC 6.1.3 Cyclo-ligases

EC 6.1.3.1 olefin β-lactone synthetase

EC 6.2 Forming Carbon-Sulfur Bonds

EC 6.2.1 Acid-Thiol Ligases

EC 6.2.1.1 acetate—CoA ligase
EC 6.2.1.2 medium-chain acyl-CoA ligase
EC 6.2.1.3 long-chain-fatty-acid—CoA ligase
EC 6.2.1.4 succinate—CoA ligase (GDP-forming)
EC 6.2.1.5 succinate—CoA ligase (ADP-forming)
EC 6.2.1.6 glutarate—CoA ligase
EC 6.2.1.7 cholate—CoA ligase
EC 6.2.1.8 oxalate—CoA ligase
EC 6.2.1.9 malate—CoA ligase
EC 6.2.1.10 acid—CoA ligase (GDP-forming)
EC 6.2.1.11 biotin—CoA ligase
EC 6.2.1.12 4-coumarate—CoA ligase
EC 6.2.1.13 acetate—CoA ligase (ADP-forming)
EC 6.2.1.14 6-carboxyhexanoate—CoA ligase
EC 6.2.1.15 arachidonate—CoA ligase
EC 6.2.1.16 acetoacetate—CoA ligase
EC 6.2.1.17 propionate—CoA ligase
EC 6.2.1.18 citrate—CoA ligase
EC 6.2.1.19 long-chain-fatty-acid—protein ligase
EC 6.2.1.20 long-chain-fatty-acid—[acyl-carrier-protein] ligase
EC 6.2.1.21 now EC 6.2.1.30
EC 6.2.1.22 [citrate (pro-3S)-lyase] ligase
EC 6.2.1.23 dicarboxylate—CoA ligase
EC 6.2.1.24 phytanate—CoA ligase
EC 6.2.1.25 benzoate—CoA ligase
EC 6.2.1.26 O-succinylbenzoate—CoA ligase
EC 6.2.1.27 4-hydroxybenzoate—CoA ligase
EC 6.2.1.28 3α,7α-dihydroxy-5β-cholestanate—CoA ligase
EC 6.2.1.29 deleted now EC 6.2.1.7
EC 6.2.1.30 phenylacetate—CoA ligase
EC 6.2.1.31 2-furoate—CoA ligase
EC 6.2.1.32 anthranilate—CoA ligase
EC 6.2.1.33 4-chlorobenzoate—CoA ligase
EC 6.2.1.34 trans-feruloyl-CoA synthase
EC 6.2.1.35 acetate—[acyl-carrier protein] ligase
EC 6.2.1.36 3-hydroxypropionyl-CoA synthase
EC 6.2.1.37 3-hydroxybenzoate—CoA ligase
EC 6.2.1.38 (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
EC 6.2.1.39 [butirosin acyl-carrier protein]—L-glutamate ligase
EC 6.2.1.40 4-hydroxybutyrate—CoA ligase (AMP-forming)
EC 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate—CoA ligase
EC 6.2.1.42 3-oxocholest-4-en-26-oate—CoA ligase
EC 6.2.1.43 2-hydroxy-7-methoxy-5-methyl-1-naphthoate—CoA ligase
EC 6.2.1.44 3-(methylthio)propionyl—CoA ligase
EC 6.2.1.45 E1 ubiquitin-activating enzyme
EC 6.2.1.46 L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase
EC 6.2.1.47 medium-chain-fatty-acid—[acyl-carrier-protein] ligase
EC 6.2.1.48 carnitine-CoA ligase
EC 6.2.1.49 long-chain fatty acid adenylyltransferase FadD28
EC 6.2.1.50 4-hydroxybenzoate adenylyltransferase FadD22
EC 6.2.1.51 4-hydroxyphenylalkanoate adenylyltransferase FadD29
EC 6.2.1.52 L-firefly luciferin—CoA ligase
EC 6.2.1.53 L-proline—[L-prolyl-carrier protein] ligase
EC 6.2.1.54 D-alanine—[D-alanyl-carrier protein] ligase (26 April 2018)
EC 6.2.1.55 E1 SAMP-activating enzyme
EC 6.2.1.56 4-hydroxybutyrate—CoA ligase (ADP-forming)
EC 6.2.1.57 long-chain fatty acid adenylase/transferase FadD23
EC 6.2.1.58 isophthalate—CoA ligase
EC 6.2.1.59 long-chain fatty acid adenylase/transferase FadD26
EC 6.2.1.60 marinolic acid—CoA ligase
EC 6.2.1.61 salicylate—[aryl-carrier protein] ligase
EC 6.2.1.62 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase
EC 6.2.1.63 L-arginine—[L-arginyl-carrier protein] ligase
EC 6.2.1.64 E1 NEDD8-activating enzyme
EC 6.2.1.65 salicylate—CoA ligase
EC 6.2.1.66 glyine—[glycyl-carrier protein] ligase
EC 6.2.1.67 L-alanine—[L-alanyl-carrier protein] ligase
EC 6.2.1.68 L-glutamate—[L-glutamyl-carrier protein] ligase
EC 6.2.1.69 L-cysteine—[L-cysteinyl-carrier protein] ligase
EC 6.2.1.70 L-threonine—[L-threonyl-carrier protein] ligase
EC 6.2.1.71 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase
EC 6.2.1.72 L-serine—[L-seryl-carrier protein] ligase
EC 6.2.1.73 L-tryptophan—[L-tryptophyl-carrier protein] ligase
EC 6.2.1.74 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase
EC 6.2.1.75 indoleacetate—CoA ligase
EC 6.2.1.76 malonate–CoA ligase

EC 6.2.2 Amide—Thiol Ligases

EC 6.2.2.1 thioglycine synthase
EC 6.2.2.2 oxazoline synthase
EC 6.2.2.3 thiazoline synthase

EC 6.3 Forming Carbon-Nitrogen Bonds

EC 6.3.1 Acid-Ammonia (or Amine) Ligases (Amide Synthases)

EC 6.3.1.1 aspartate—ammonia ligase
EC 6.3.1.2 glutamine synthetase
EC 6.3.1.3 now EC 6.3.4.13
EC 6.3.1.4 aspartate—ammonia ligase (ADP-forming)
EC 6.3.1.5 NAD⁺ synthase
EC 6.3.1.6 glutamate—ethylamine ligase
EC 6.3.1.7 4-methyleneglutamate—ammonia ligase
EC 6.3.1.8 glutathionylspermidine synthase
EC 6.3.1.9 trypanothione synthase
EC 6.3.1.11 glutamate—putrescine ligase
EC 6.3.1.12 D-aspartate ligase)
EC 6.3.1.13 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase
EC 6.3.1.14 diphthine—ammonia ligase
EC 6.3.1.15 8-demethylnovobiocic acid synthase
EC 6.3.1.16 transferred, misclassified, see EC 6.3.3.6
EC 6.3.1.17 β-citrylglutamate synthase
EC 6.3.1.18 γ-glutamylanilide synthase
EC 6.3.1.10 adenosylcobinamide-phosphate synthase
EC 6.3.1.19 prokaryotic ubiquitin-like protein ligase
EC 6.3.1.20 lipoate—protein ligase
EC 6.3.1.21 phosphoribosylglycinamide formyltransferase 2
EC 6.3.1.22 tRNAmet cytidine acetate ligase

EC 6.3.2 Acid—Amino-Acid Ligases (Peptide Synthases)

EC 6.3.2.1 pantoate—β-alanine ligase (AMP-forming)
EC 6.3.2.2 glutamate—cysteine ligase
EC 6.3.2.3 glutathione synthase
EC 6.3.2.4 D-alanine—D-alanine ligase
EC 6.3.2.5 phosphopantothenate—cysteine ligase (CTP)
EC 6.3.2.6 phosphoribosylaminoimidazolesuccinocarboxamide synthase
EC 6.3.2.7 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
EC 6.3.5.8 now EC 2.6.1.85
EC 6.3.2.9 UDP-N-acetylmuramoylalanine—D-glutamate ligase
EC 6.3.2.10 UDP-N-acetylmuramoylalanyl-tripeptide—D-alanyl-D-alanine ligase
EC 6.3.2.11 carnosine synthase
EC 6.3.2.12 dihydrofolate synthase
EC 6.3.2.13 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase
EC 6.3.2.14 enterobactin synthase
EC 6.3.2.15 deleted, due to EC 6.3.2.10
EC 6.3.2.16 D-alanine—alanyl-poly(glycerolphosphate) ligase
EC 6.3.2.17 tetrahydrofolate synthase
EC 6.3.2.18 γ-glutamylhistamine synthase
EC 6.3.2.19 deleted now covered by EC 6.2.1.45, EC 2.3.2.23 and EC 2.3.2.27
EC 6.3.2.20 indoleacetate—lysine synthetase
EC 6.3.2.21 deleted now covered by EC 6.2.1.45 and EC 2.3.2.27
EC 6.3.2.22 deleted now EC 6.3.1.14
EC 6.3.2.23 homoglutathione synthase
EC 6.3.2.24 tyrosine—arginine ligase
EC 6.3.2.25 tubulin—tyrosine ligase
EC 6.3.2.26 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
EC 6.3.2.27 deleted now covered by EC 6.3.2.38 and EC 6.3.2.39
EC 6.3.2.28 transferred now EC 6.3.2.49
EC 6.3.2.29 cyanophycin synthase (L-aspartate-adding)
EC 6.3.2.30 cyanophycin synthase (L-arginine-adding)
EC 6.3.2.31 coenzyme F₄₂₀-0:L-glutamate ligase
EC 6.3.2.32 coenzyme γ-F₄₂₀-2:α-L-glutamate ligase
EC 6.3.2.33 tetrahydrosarcinapterin synthase
EC 6.3.2.34 coenzyme F₄₂₀-1:γ-L-glutamate ligase
EC 6.3.2.35 D-alanine—D-serine ligase
EC 6.3.2.36 4-phosphopantoate—β-alanine ligase
EC 6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
EC 6.3.2.38 N²-citryl-N⁶-acetyl-N⁶-hydroxylysine synthase
EC 6.3.2.39 aerobactin synthase
EC 6.3.2.40 cyclopeptine synthase
EC 6.3.2.41 N-acetylaspartylglutamate synthase
EC 6.3.2.42 N-acetylaspartylglutamylglutamate synthase
EC 6.3.2.43 [amino group carrier protein]—L-2-aminoadipate ligase
EC 6.3.2.44 pantoate—β-alanine ligase (ADP-forming)
EC 6.3.2.45 UDP-N-acetylmuramate L-alanyl-γ-D-glutamyl-meso-2,6-diaminoheptanedioate ligase
EC 6.3.2.46 fumarate—(S)-2,3-diaminopropanoate ligase
EC 6.3.2.47 dapdiamide synthase
EC 6.3.2.48 L-arginine-specific L-amino acid ligase
EC 6.3.2.49 L-alanine-L-anticapsin ligase
EC 6.3.2.50 tenuazonic acid synthetase
EC 6.3.2.51 phosphopantothenate—cysteine ligase (ATP)
EC 6.3.2.52 jasmonoyl—L-amino acid ligase
EC 6.3.2.53 UDP-N-acetylmuramoyl-L-alanine—L-glutamate ligase
EC 6.3.2.54 L-2,3-diaminopropanoate—citrate ligase
EC 6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase
EC 6.3.2.56 staphyloferrin B synthase
EC 6.3.2.57 staphyloferrin A synthase
EC 6.3.2.58 D-ornithine—citrate ligase
EC 6.3.2.59 3-methyl-D-ornithine—L-lysine ligase
EC 6.3.2.60 glutamate—[amino group carrier protein] ligase
EC 6.3.2.61 tubulin-glutamate ligase
EC 6.3.2.62 β-tubulin-glutamate ligase
EC 6.3.2.63 putrebactin synthase
EC 6.3.2.64 bisucaberin synthase

EC 6.3.3 Cyclo-Ligases

EC 6.3.3.1 phosphoribosylformylglycinamidine cyclo-ligase
EC 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase
EC 6.3.3.3 dethiobiotin synthase
EC 6.3.3.4 (carboxyethyl)arginine β-lactam-synthase
EC 6.3.3.5 O-ureido-D-serine cyclo-ligase
EC 6.3.3.6 carbapenam-3-carboxylate synthase

EC 6.3.4 Other Carbon-Nitrogen Ligases

EC 6.3.4.1 transferred now included in EC 6.3.5.2
EC 6.3.4.2 CTP synthase (glutamine hydrolysing)
EC 6.3.4.3 formate—tetrahydrofolate ligase
EC 6.3.4.4 adenylosuccinate synthase
EC 6.3.4.5 argininosuccinate synthase
EC 6.3.4.6 urea carboxylase
EC 6.3.4.7 ribose-5-phosphate—ammonia ligase
EC 6.3.4.8 imidazoleacetate—phosphoribosyldiphosphate ligase
EC 6.3.4.9 biotin—[methylmalonyl-CoA-carboxytransferase] ligase
EC 6.3.4.10 biotin—[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase
EC 6.3.4.11 biotin—[methylcrotonoyl-CoA-carboxylase] ligase
EC 6.3.4.12 glutamate—methylamine ligase
EC 6.3.4.13 phosphoribosylamine—glycine ligase
EC 6.3.4.14 biotin carboxylase
EC 6.3.4.15 biotin—[biotin carboxyl-carrier protein] ligase
EC 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
EC 6.3.4.17 formate—dihydrofolate ligase
EC 6.3.4.18 5-(carboxyamino)imidazole ribonucleotide synthase
EC 6.3.4.19 tRNA^Ile-lysidine synthetase
EC 6.3.4.20 7-cyano-7-deazaguanine synthase
EC 6.3.4.21 nicotinate phosphoribosyltransferase
EC 6.3.4.22 tRNA^Ile2-agmatinylcytidine synthase
EC 6.3.4.23 formate—phosphoribosylaminoimidazolecarboxamide ligase
EC 6.3.4.24 tyramine—L-glutamate ligase

EC 6.3.4.25 2-amino-2′-deoxyadenylo-succinate synthase
EC 6.3.5 Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor

EC 6.3.5.1 NAD⁺ synthase (glutamine-hydrolysing)
EC 6.3.5.2 GMP synthase (glutamine-hydrolysing)
EC 6.3.5.3 phosphoribosylformylglycinamidine synthase
EC 6.3.5.4 asparagine synthase (glutamine-hydrolysing)
EC 6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)
EC 6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing)
EC 6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing)
EC 6.3.5.8 aminodeoxychorismate synthase
EC 6.3.5.9 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
EC 6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolysing)
EC 6.3.5.11 cobyrinate a,c-diamide synthase
EC 6.3.5.12 Ni-sirohydrochlorin a,c-diamide synthase
EC 6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing)

EC 6.4 Forming Carbon-Carbon Bonds

EC 6.4.1.1 pyruvate carboxylase
EC 6.4.1.2 acetyl-CoA carboxylase
EC 6.4.1.3 propionyl-CoA carboxylase
EC 6.4.1.4 methylcrotonoyl-CoA carboxylase
EC 6.4.1.5 geranoyl-CoA carboxylase
EC 6.4.1.6 acetone carboxylase
EC 6.4.1.7 2-oxoglutarate carboxylase
EC 6.4.1.8 acetophenone carboxylase

EC 6.5 Forming Phosphoric Ester Bonds

EC 6.5.1.1 DNA ligase (ATP)
EC 6.5.1.2 DNA ligase (NAD⁺)
EC 6.5.1.3 RNA ligase (ATP)
EC 6.5.1.4 RNA 3'-terminal-phosphate cyclase (ATP)
EC 6.5.1.5 RNA 3'-terminal-phosphate cyclase (GTP)
EC 6.5.1.6 DNA ligase (ATP or NAD⁺)
EC 6.5.1.7 DNA ligase (ATP, ADP or GTP)
EC 6.5.1.8 3'-phosphate/5'-hydroxy nucleic acid ligase
EC 6.5.1.9 cyclic 2,3-diphosphoglycerate synthase

EC 6.6 Forming Nitrogen—Metal Bonds

EC 6.6.1 Forming Coordination Complexes

EC 6.6.1.1 magnesium chelatase
EC 6.6.1.2 cobaltochelatase

EC 6.7 Forming nitrogen-nitrogen bonds

EC 6.7.1 Forming diazo bonds

EC 6.7.1.1 3-amino-2-hydroxy-4-methoxybenzoate diazotase
EC 6.7.1.2 3-aminoavenalumate diazotase