IUBMB Enzyme Nomenclature


Accepted name: ABC-type Ni2+ transporter

Reaction: ATP + H2O + Ni2+-[nickel-binding protein][side 1] = ADP + phosphate + Ni2+[side 2] + [nickel-binding protein][side 1]

Other name(s): nickel ABC transporter; nickel-transporting ATPase; ABC-type nickel-transporter

Systematic name: ATP phosphohydrolase (ABC-type, Ni2+-importing)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Ni2+; the identity of the nickel species transported has not been conclusively established. Does not undergo phosphorylation during the transport process.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res. Microbiol. 146 (1995) 271-278. [PMID: 7569321]

2. Hendricks, J.K. and Mobley, H.L. Helicobacter pylori ABC transporter: effect of allelic exchange mutagenesis on urease activity. J. Bacteriol. 179 (1997) 5892-5902. [PMID: 9294450]

3. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

4. Griffiths, J.K. and Sansom, C.E. The Transporter Factsbook, Academic Press, San Diego, 1998.

[EC created 2000 as EC, transferred 2018 to EC]

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