IUBMB Enzyme Nomenclature


Accepted name: P-type Zn2+ transporter

Reaction: ATP + H2O + Zn2+[side 1] = ADP + phosphate + Zn2+[side 2]

Other name(s): Zn(II)-translocating P-type ATPase; Zn2+-exporting ATPase; P1B-type ATPase; HMA4 (gene name); zntA (gene name)

Systematic name: ATP phosphohydrolase (P-type, Zn2+-exporting)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme, present in prokaryotes and photosynthetic eukaryotes, exports Zn2+ and the related cations Cd2+ and Pb2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Beard, S.J., Hashim, R., Membrillo-Hernández, J., Hughes, M.N. and Poole, R.K. Zinc(II) tolerance in Escherichia coli K-12: evidence that the zntA gene (o732) encodes a cation transport ATPase. Mol. Microbiol. 25 (1997) 883-891. [PMID: 9364914]

2. Rensing, C., Mitra, B. and Rosen, B.P. The zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase. Proc. Natl. Acad. Sci. USA 94 (1997) 14326-14331. [PMID: 9405611]

3. Rensing, C., Sun, Y., Mitra, B. and Rosen, B.P. Pb(II)-translocating P-type ATPases. J. Biol. Chem. 273 (1998) 32614-32617. [PMID: 9830000]

4. Mills, R.F., Francini, A., Ferreira da Rocha, P.S., Baccarini, P.J., Aylett, M., Krijger, G.C. and Williams, L.E. The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels. FEBS Lett. 579 (2005) 783-791. [PMID: 15670847]

5. Eren, E. and Argüello, J.M. Arabidopsis HMA2, a divalent heavy metal-transporting P(IB)-type ATPase, is involved in cytoplasmic Zn2+ homeostasis. Plant Physiol. 136 (2004) 3712-3723. [PMID: 15475410]

[EC created 2000 as EC, modified 2001, modified 2006, transferred 2018 to EC]

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