IUBMB Enzyme Nomenclature


Accepted name: Na+/K+-exchanging ATPase

Reaction: ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1]

Other name(s): (Na+ + K+)-activated ATPase; Na,K-activated ATPase; Na,K-pump; Na+,K+-ATPase; sodium/potassium-transporting ATPase; Na+/K+-exchanging ATPase

Systematic name: ATP phosphohydrolase (P-type, Na+/K+-exchanging)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Skou, J.C. The influence of some cations on an adenosinetriphosphatase from peripheral nerve. Biochim. Biophys. Acta 23 (1957) 394-401. [PMID: 13412736]

2. Post, R.L., Sen, A.K. and Rosenthal, A.S. A phosphorylated intermediate in adenosine triphosphate-dependent sodium and potassium transport across kidney membrane. J. Biol. Chem. 240 (1965) 1437-1445. [PMID: 14284759]

3. Skou, J.C. The energy-coupled exchange of Na+ for K+ across the cell membrane. The Na+,K+ pump. FEBS Lett. 268 (1990) 314-324. [PMID: 2166689]

4. Castillo, J.P., Rui, H., Basilio, D., Das, A., Roux, B., Latorre, R., Bezanilla, F. and Holmgren, M. Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase. Nat Commun 6 (2015) 7622. [PMID: 26205423]

[EC created 1984 EC, transferred 2000 to EC, modified 2001, transferred 2018 to EC]

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