IUBMB Enzyme Nomenclature


Accepted name: ABC-type ferric enterobactin transporter

Reaction: ATP + H2O + Fe3+-enterobactin complex-[enterobactin-binding protein][side 1] = ADP + phosphate + Fe3+-enterobactin complex[side 2] + [enterobactin-binding protein][side 1]

Other name(s): ferric enterobactin transporting ATPase; ferric enterobactin ABC transporter; fepBCDG (gene names)

Systematic name: ATP phosphohydrolase (ABC-type, iron(III) enterobactin-importing)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity uptake of Fe3+-enterobactin complexes.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Chenault, S.S. and Earhart, C.F. Organization of genes encoding membrane proteins of the Escherichia coli ferrienterobactin permease. Mol. Microbiol. 5 (1991) 1405-1413. [PMID: 1787794]

2. Shea, C.M. and McIntosh, M.A. Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding-protein-dependent systems in Escherichia coli. Mol. Microbiol. 5 (1991) 1415-1428. [PMID: 1838574]

[EC created 2000 as EC, part transferred 2018 to EC]

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