IUBMB Enzyme Nomenclature


Accepted name: H+/K+-exchanging ATPase

Reaction: ATP + H2O + H+[side 1] + K+[side 2] = ADP + phosphate + H+[side 2] + K+[side 1]

Other name(s): H+-K+-ATPase; H,K-ATPase; (K+ + H+)-ATPase

Systematic name: ATP phosphohydrolase (P-type,H+/K+-exchanging)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. A gastric mucosal enzyme that catalyses the efflux of one H+ and the influx of one K+ per ATP hydrolysed.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Sachs, G., Collier, R.H., Shoemaker, R.L. and Hirschowitz, B.I. The energy source for gastric H+ secretion. Biochim. Biophys. Acta 162 (1968) 210-219. [PMID: 5682852]

2. Hersey, S.J., Perez, A. Matheravidathu, S. and Sachs, G. Gastric H+-K+-ATPase in situ: evidence for compartmentalization. Am. J. Physiol. 257 (1989) G539-G547. [PMID: 2552824]

3. Rabon, E.C. and Reuben, M.A. The mechanism and structure of the gastric H,K-ATPase. Annu. Rev. Physiol. 52 (1990) 321-344. [PMID: 2158765]

[EC created 1984 as EC, transferred 2000 to EC, transferred 2018 to EC]

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