IUBMB Enzyme Nomenclature


Accepted name: ABC-type Mn2+ transporter

Reaction: ATP + H2O + Mn2+-[manganese-binding protein][side 1] = ADP + phosphate + Mn2+[side 2] + [manganese-binding protein][side 1]

Other name(s): ABC-type manganese permease complex; manganese-transporting ATPase (ambiguous); ABC-type manganese transporter

Systematic name: ATP phosphohydrolase (ABC-type, Mn2+-importing)

Comments: ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of Mn2+, Zn2+ and iron chelates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res. Microbiol. 146 (1995) 271-278. [PMID: 7569321]

2. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

3. Novak, R., Braun, J.S., Charpentier, E. and Tuomanen, E. Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa. Mol. Microbiol. 29 (1998) 1285-1296. [PMID: 9767595]

4. Kolenbrander, P.E., Andersen, R.N., Baker, R.A. and Jenkinson, H.F. The adhesion-assoiated aca operon in Streptococcus gordonii encodes an inducible high-affinity ABC transporter for Mn2+ uptake. J. Bacteriol. 180 (1998) 290-295. [PMID: 9440518]

[EC created 2000 as EC, transferred 2018 to EC]

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