IUBMB Enzyme Nomenclature


Accepted name: P-type Cu2+ transporter

Reaction: ATP + H2O + Cu2+[side 1] = ADP + phosphate + Cu2+[side 2]

Other name(s): Cu2+-exporting ATPase; copB (gene name)

Systematic name: ATP phosphohydrolase (P-type, Cu2+-exporting)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. The enzyme from the termophilic archaeon Archaeoglobus fulgidus is involved in copper extrusion from the cell [1,2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Mana-Capelli, S., Mandal, A.K. and Arguello, J.M. Archaeoglobus fulgidus CopB is a thermophilic Cu2+-ATPase: functional role of its histidine-rich-N-terminal metal binding domain. J. Biol. Chem. 278 (2003) 40534-40541. [PMID: 12876283]

2. Jayakanthan, S., Roberts, S.A., Weichsel, A., Arguello, J.M. and McEvoy, M.M. Conformations of the apo-, substrate-bound and phosphate-bound ATP-binding domain of the Cu(II) ATPase CopB illustrate coupling of domain movement to the catalytic cycle. Biosci Rep 32 (2012) 443-453. [PMID: 22663904]

[EC created 2000 as EC, modified 2013, transferred 2018 to EC]

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