IUBMB Enzyme Nomenclature


Accepted name: Na+-exporting diphosphatase

Reaction: diphosphate + H2O + Na+[side 1] = 2 phosphate + Na+[side 2]

Other name(s): Na+-translocating membrane pyrophosphatase; sodium-translocating pyrophosphatase

Systematic name: diphosphate phosphohydrolase (Na+-transporting)

Comments: Requires Na+ and K+. This enzyme, found in some bacteria and archaea, couples the energy from diphosphate hydrolysis to active sodium translocation across the membrane. The enzyme is electrogenic, as the Na+ transport results in generation of a positive potential in the inner side of the membrane.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Belogurov, G.A., Malinen, A.M., Turkina, M.V., Jalonen, U., Rytkonen, K., Baykov, A.A. and Lahti, R. Membrane-bound pyrophosphatase of Thermotoga maritima requires sodium for activity. Biochemistry 44 (2005) 2088-2096. [PMID: 15697234]

2. Malinen, A.M., Belogurov, G.A., Baykov, A.A. and Lahti, R. Na+-pyrophosphatase: a novel primary sodium pump. Biochemistry 46 (2007) 8872-8878. [PMID: 17605473]

3. Luoto, H.H., Belogurov, G.A., Baykov, A.A., Lahti, R. and Malinen, A.M. Na+-translocating membrane pyrophosphatases are widespread in the microbial world and evolutionarily precede H+-translocating pyrophosphatases. J. Biol. Chem. 286 (2011) 21633-21642. [PMID: 21527638]

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