EC 7.4.2.12

Reaction: (1) ATP + H₂O + L-cystine-[cystine-binding protein]_{[side 1]} = ADP + phosphate + L-cystine_{[side 2]} + [cystine-binding protein]_{[side 1]}
(2) ATP + H₂O + D-cystine-[cystine-binding protein]_{[side 1]} = ADP + phosphate + D-cystine_{[side 2]} + [cystine-binding protein]_{[side 1]}

Other name(s): cystine transporting ATPase; cystine ABC transporter

Systematic name: ATP phosphohydrolase (ABC-type, cystine-importing)

Comments: ABC-type (ATP-binding cassette-type) transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the high affinity import of trace cystine. The enzyme from Escherichia coli K-12 can import both isomers of cystine and a variety of related molecules including djenkolate, lanthionine, diaminopimelate and homocystine.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Berger, E.A. and Heppel, L.A. A binding protein involved in the transport of cystine and diaminopimelic acid in Escherichia coli. J. Biol. Chem 247 (1972) 7684-7694. [PMID: 4564569]

2. Chonoles Imlay, K.R., Korshunov, S. and Imlay, J.A. Physiological roles and adverse effects of the two cystine importers of Escherichia coli. J. Bacteriol. 197 (2015) 3629-3644. [PMID: 26350134]