IUBMB Enzyme Nomenclature


Accepted name: ABC-type oligopeptide transporter

Reaction: ATP + H2O + oligopeptide-[oligopeptide-binding protein][side 1] = ADP + phosphate + oligopeptide[side 2] + [oligopeptide-binding protein][side 1]

Other name(s): oligopeptide permease; OppBCDF; oligopeptide ABC transporter; oligopeptide-transporting ATPase

Systematic name: ATP phosphohydrolase (ABC-type, oligopeptide-importing)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the import of oligopeptides of varying nature. The binding protein determines the specificity of the system. cf. EC, ABC-type dipeptide transporter.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Kuan, G., Dassa, E., Saurin, N., Hofnung, M. and Saier, M.H., Jr. Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases. Res. Microbiol. 146 (1995) 271-278. [PMID: 7569321]

2. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

3. Griffiths, J.K. and Sansom, C.E. The Transporter Factsbook, Academic Press, San Diego, 1998.

4. Pearce, S.R., Mimmack, M.L., Gallagher, M.P., Gileadi, U., Hyde, S.C. and Higgins, C.F. Membrane topology of the integral membrane components, OppB and OppC, of the oligopeptide permease of Salmonella typhimurium. Mol. Microbiol. 6 (1992) 47-57. [PMID: 1738314]

[EC created 2000 as EC, transferred 2018 to EC]

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