Reaction: ATP + H2O + α-factor[side 1] = ADP + phosphate + α-factor[side 2]
Other name(s): α-factor-transporting ATPase; α-factor-pheromone transporting ATPase
Systematic name: ATP phosphohydrolase (ABC-type, α-factor-exporting)
Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports the α-factor sex pheromone.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Michaelis, S. STE6, the yeast α-factor exporter. Semin. Cell Biol. 4 (1993) 17-27. [PMID: 8095825]
2. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]