Reaction: ATP + H2O + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran-[AI-2-binding protein][side 1] = ADP + phosphate + (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran[side 2] + [AI-2-binding protein][side 1]
Glossary: autoinducer-2 = AI-2 = (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran
Other name(s): autoinducer-2 transporting ATPase; autoinducer-2 ABC transporter; LsrACDB (gene names)
Systematic name: ATP phosphohydrolase (ABC-type, AI-2 importing)
Comments: ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of the signalling molecule (2R,4S)-2-methyl-2,3,3,4-tetrahydoxytetrahydrofuran (also known as autoinducer-2).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Taga, M.E., Semmelhack, J.L. and Bassler, B.L. The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol. Microbiol. 42 (2001) 777-793. [PMID: 11722742]
2. Xavier, K.B. and Bassler, B.L. Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J. Bacteriol. 187 (2005) 238-248. [PMID: 15601708]