Reaction: ATP + H2O + guanine[side 1] = ADP + phosphate + guanine[side 2]
Other name(s): guanine-transporting ATPase; white (gene name); brown (gene name)
Systematic name: ATP phosphohydrolase (ABC-type, guanine-importing)
Comments: An ATP-binding cassette (ABC) type transporter found in insects that transports guanine and other purines into pigment granules in the eye, where they are converted to pteridine pigments. The transporter is a hererodimer composed of two different peptides, each containing one membrane-spanning and one cytoplasmic ATP-binding domain. In Drosophila, this transporter is encoded by the white and brown genes.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
References:
1. Sullivan, D.T., Bell, L.A., Paton, D.R. and Sullivan, M.C. Purine transport by malpighian tubules of pteridine-deficient eye color mutants of Drosophila melanogaster. Biochem. Genet. 17 (1979) 565-573. [PMID: 117796]
2. Dreesen, T.D., Johnson, D.H and Henikoff, S. The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes. Mol. Cell Biol. 8 (1988) 5206-5215. [PMID: 3149712]
3. Tearle, R.G., Belote, J.M., McKeown, M., Baker, B.S. and Howells, A.J. Cloning and characterization of the scarlet gene of Drosophila melanogaster. Genetics 122 (1989) 595-606. [PMID: 2503416]
4. Griffiths, J.K. and Sansom, C.E. The Transporter Factsbook, Academic Press, San Diego, 1998.
5. Mackenzie, S.M., Brooker, M.R., Gill, T.R., Cox, G.B., Howells, A.J. and Ewart, G.D. Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration. Biochim. Biophys. Acta 1419 (1999) 173-185. [PMID: 10407069]