Mechanism of EC 1.21.3.1
isopenicillin-N synthase

The mechanism below rationalizes the reaction mechanism, see Roach, P.L., Clifton, I.J., Hensgens, C.M., Shibata, N., Schofield, C.J., Hajdu, J. and Baldwin, J.E. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature 387 (1997) 827-830. [PMID: 9194566]

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EC 1.21.3.1 isopenicillin-N synthase