The mechanism below rationalizes the rearrangement, based on Rétey, J. The urocanase story: a novel role of NAD+ as electrophile Arch. Biochem. Biophys. 314 (1994) 1-16. [PMID: 7944380]
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histidine catabolism
EC 4.2.1.49 urocanate hydratase