Mechanism of Dehydrosecodine, Catharanthine and Tabersonine Biosynthesis

EC 1.14.19.80

Mechanism based on Caputi, L, Franke, J, Farrow, S C, Chung K, Payne, R M E, Nguyen, T-D, Dang, T-T T, Carqueijeiro, I S T, Koudounas, K, Bernonville, T D de, Ameyaw, B, Jones, D M, Vieira, I J C, Courdavault, V, and O’Connor, S E, Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle Science 360 (2018) 1235-1239. [PMID: 29724909]

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dehydroprecondylocarpin acetate biosynthesis
EC 5.5.1.37 catharenthine synthase
EC 5.5.1.38 tabersonine synthase