Mechanism of EC 4.1.99.12

3,4-dihydroxy-2-butanone-4-phosphate synthase

The mechanism below rationalizes the reaction mechanism, based on Fischer, M., Romisch, W., Schiffmann, S., Kelly, M., Oschkinat, H., Steinbacher, S., Huber, R., Eisenreich, W., Richter, G. and Bacher, A. Biosynthesis of riboflavin in archaea studies on the mechanism of 3,4-dihydroxy-2-butanone-4-phosphate synthase of Methanococcus jannaschii. J. Biol. Chem. 277 (2002) 41410-41416. [PMID: 12200440] and Steinbacher, S., Schiffmann, S., Richter, G., Huber, R., Bacher, A. and Fischer, M. Structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase from Methanococcus jannaschii in complex with divalent metal ions and the substrate ribulose 5-phosphate: implications for the catalytic mechanism. J. Biol. Chem. 278 (2003) 42256-42265. [PMID: 12904291]

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riboflavin biosynthesis (late stages)
EC 4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase