Demethylsterigmatocystin Synthase
mechanism
Suggested mechanism based on Henry, K.M. and Townsend, C.A. Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites. J. Am. Chem. Soc. 127 (2005) 3724-3733, [PMID: 15771506], and Ehrlich, K.C., Montalbano, B., Boué, S.M. and Bhatnagar, D. An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin. Appl. Environ. Microbiol. 71 (2005) 8963-8965. [PMID: 22069531]. Genetic evidence strongly suggests that two enzymes are required for these reactions, a cytochrome P-450 oxidoreductase, AflN, and probable an NADPH-dependent oxidoreductase, AflM.
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