Mannosyl-glycoprotein N-acetylglucosaminyltransferases

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© IUBMB 2001

Polysaccharide representation based on Nomenclature of Carbohydrates 2carb-38.5.

For each reaction the new bond between GlcNAC and Man is bold to highlighted its position.

These enzymes probably act in numerical order, except that transferases III and IV probably compete for the same acceptor. The product formed by transferase III is not considered an acceptor for further N-acetylglucosaminyltransferase action. For reviews, see:

1. Palcic, M.M. Glycosyltransferases in glycobiology. Methods Enzymol. 230 (1994) 300-316. [PMID: 8139503]

2. Schachter, H. The joys of HexNAc. The synthesis and function of N- and O-glycan branches. Glycoconj. J. 17 (2000) 465-483. [PMID: 11421343]

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EC α-1,3-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase
EC α-1,6-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase
EC β-1,4-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase
EC α-1,3-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase
EC α-1,6-mannosyl-glycoprotein 6-β-N-acetylglucosaminyltransferase
EC α-1,6-mannosyl-glycoprotein 4-β-N-acetylglucosaminyltransferase
EC mannosyl-oligosaccharide 1,3-1,6-α-mannosidase