Mechanism for formation of sulfenic acid
The mechanism below rationalizes the reaction mechanism of the formation of the sulfenic acid, see Wood, Z.A., Schröder, E., Harris, J.R. and Poole, L.B. Structure, mechanism and regulation of peroxiredoxins. Trends Biochem. Sci. 28 (2003) 32-40. [PMID: 12517450]
© IUBMB 2004
It is possible that a base B: in the protein assists the cysteine residue to lose H+, and that its protonated form assists the RO- group to leave the peroxide. The S- form of the cysteine may be stabilized by an arginine residue, whose guanidino group is shown.
EC 18.104.22.168 see below
EC 22.214.171.124, thioredoxin-dependent peroxiredoxin
EC 126.96.36.199, glutaredoxin-dependent peroxiredoxin
EC 188.8.131.52, NADH-dependent peroxiredoxin
EC 184.108.40.206, glutathione-dependent peroxiredoxin
EC 220.127.116.11, lipoyl-dependent peroxiredoxin
EC 18.104.22.168, mycoredoxin-dependent peroxiredoxin.