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enzymes homepage farnesyl diphosphate biosynthesis sesquiterpenoid biosynthesis EC 4.2.3.166 (+)-(1E,4E,6S,7S)-germacra-1(10),4-dien-6-ol synthase EC 4.2.3.174 (2E,6E)-hedycaryol synthase EC 4.2.3.187 (2Z,6E)-hedycaryol synthase