New enzymes (30 April 2015, approved 28 May 2015)The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (21 August 2015, approved 17 September 2015)
New enzymes (10 November 2015, approved 7 December 2015)
*EC 1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)
EC 1.2.98.1 formaldehyde dismutase
EC 1.21.1.1 iodotyrosine deiodinase
*EC 1.1.1.86 ketol-acid reductoisomerase (NADP+)
*EC 1.1.1.276 serine 3-dehydrogenase (NADP+)
*EC 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
*EC 1.1.1.381 3-hydroxy acid dehydrogenase
EC 1.1.1.382 ketol-acid reductoisomerase (NAD+)
EC 1.1.1.383 ketol-acid reductoisomerase [NAD(P)+]
EC 1.1.1.384 dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase
EC 1.1.1.385 dihydroanticapsin dehydrogenase
EC 1.1.1.386 ipsdienol dehydrogenase
EC 1.1.1.387 L-serine 3-dehydrogenase (NAD+)
EC 1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)
EC 1.1.1.389 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase
EC 1.1.1.390 sulfoquinovose 1-dehydrogenase
EC 1.1.3.48 3-deoxy-α-D-manno-octulosonate 8-oxidase
*EC 1.2.1.64 4-hydroxybenzaldehyde dehydrogenase (NAD+)
EC 1.2.1.93 formate dehydrogenase (NAD+, ferredoxin)
EC 1.2.1.94 farnesal dehydrogenase
EC 1.2.1.95 L-2-aminoadipate reductase
EC 1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)
EC 1.2.1.97 3-sulfolactaldehyde dehydrogenase
EC 1.2.5.2 aldehyde dehydrogenase (quinone)
EC 1.2.98 With other, known, physiological acceptors
EC 1.2.99.3 transferred now EC 1.2.5.2
EC 1.2.99.4 transferred now EC 1.2.98.1
EC 1.3.1.35 transferred now EC 1.14.19.22
*EC 1.3.1.43 arogenate dehydrogenase
EC 1.3.1.63 transferred now EC 1.21.1.2
EC 1.3.1.108 caffeoyl-CoA reductase
EC 1.3.1.109 butanoyl-CoA dehydrogenase (NAD+, ferredoxin)
EC 1.3.1.110 lactate dehydrogenase (NAD+, ferredoxin)
EC 1.3.7.11 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
EC 1.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase
EC 1.3.99.34 transferred now EC 1.3.7.11
EC 1.3.99.37 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
EC 1.4.99.1 transferred now EC 1.4.99.6
EC 1.4.99.6 D-arginine dehydrogenase
*EC 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
*EC 1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
EC 1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]
EC 1.5.1.50 dihydromonapterin reductase
*EC 1.5.3.5 (S)-6-hydroxynicotine oxidase
*EC 1.5.3.6 (R)-6-hydroxynicotine oxidase
EC 1.6.1.4 NAD(P)+ transhydrogenase (ferredoxin)
EC 1.6.1.5 proton-translocating NAD(P)+ transhydrogenase
*EC 1.6.3.5 renalase
EC 1.6.5.11 NADH dehydrogenase (quinone)
EC 1.6.5.12 demethylphylloquinone reductase
EC 1.6.99.5 transferred now EC 1.6.5.11
*EC 1.7.3.6 hydroxylamine oxidase (cytochrome)
*EC 1.8.1.2 assimilatory sulfite reductase (NADPH)
*EC 1.8.7.1 assimilatory sulfite reductase (ferredoxin)
EC 1.8.99.1 deleted now covered by EC 1.8.1.2 and EC 1.8.7.1
EC 1.8.99.5 dissimilatory sulfite reductase
EC 1.10.5 With a quinone or related compound as acceptor
EC 1.10.5.1 ribosyldihydronicotinamide dehydrogenase (quinone)
EC 1.10.99.2 transferred now EC 1.10.5.1
EC 1.10.99.3 transferred now EC 1.23.5.1
*EC 1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase
*EC 1.11.1.19 dye decolorizing peroxidase
*EC 1.13.11.18 persulfide dioxygenase
EC 1.13.11.80 (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
EC 1.13.11.81 7,8-dihydroneopterin oxygenase
EC 1.13.11.82 8'-apo-carotenoid 13,14-cleaving dioxygenase
EC 1.13.12.22 deoxynogalonate monooxygenase
EC 1.14.11.48 xanthine dioxygenase
EC 1.14.11.49 uridine-5'-phosphate dioxygenase
EC 1.14.12.21 transferred now EC 1.14.13.208
EC 1.14.12.23 nitroarene dioxygenase
EC 1.14.12.24 2,4-dinitrotoluene dioxygenase
EC 1.14.13.26 transferred now EC 1.14.18.4
EC 1.14.13.95 transferred now EC 1.14.18.8
EC 1.14.13.132 transferred now EC 1.14.14.17
EC 1.14.13.169 transferred now EC 1.14.18.5
*EC 1.14.13.190 ferruginol synthase
EC 1.14.13.201 β-amyrin 28-monooxygenase
EC 1.14.13.202 methyl farnesoate epoxidase
EC 1.14.13.203 farnesoate epoxidase
EC 1.14.13.204 long-chain acyl-CoA ω-monooxygenase
EC 1.14.13.205 long-chain fatty acid ω-monooxygenase
EC 1.14.13.206 laurate 7-monooxygenase
EC 1.14.13.207 ipsdienol synthase
EC 1.14.13.208 benzoyl-CoA 2,3-epoxidase
EC 1.14.13.209 salicyloyl-CoA 5-hydroxylase
*EC 1.14.14.1 unspecific monooxygenase
EC 1.14.14.16 steroid 21-monooxygenase
EC 1.14.14.17 squalene monooxygenase
EC 1.14.14.18 heme oxygenase (biliverdin-producing)
EC 1.14.14.19 steroid 17α-monooxygenase
EC 1.14.15.14 methyl-branched lipid ω-hydroxylase
EC 1.14.18.4 phosphatidylcholine 12-monooxygenase
EC 1.14.18.5 sphingolipid C4-monooxygenase
EC 1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
EC 1.14.18.7 dihydroceramide fatty acyl 2-hydroxylase
EC 1.14.18.8 7α-hydroxycholest-4-en-3-one 12α-hydroxylase
*EC 1.14.19.2 stearoyl-[acyl-carrier-protein] 9-desaturase
*EC 1.14.19.3 acyl-CoA 6-desaturase
*EC 1.14.19.4 acyl-lipid (11-3)-desaturase
*EC 1.14.19.5 acyl-CoA 11-(Z)-desaturase
*EC 1.14.19.6 acyl-CoA (9+3)-desaturase
EC 1.14.19.10 icosanoyl-CoA 5-desaturase
EC 1.14.19.11 palmitoyl-[acyl-carrier-protein] 4-desaturase
EC 1.14.19.12 acyl-lipid ω-(9-4) desaturase
EC 1.14.19.13 acyl-CoA 15-desaturase
EC 1.14.19.14 linoleoyl-lipid Δ9 conjugase
EC 1.14.19.15 (11Z)-hexadec-11-enoyl-CoA conjugase
EC 1.14.19.16 linoleoyl-lipid Δ12 conjugase (11E,13Z-forming)
EC 1.14.19.17 sphingolipid 4-desaturase
EC 1.14.19.18 sphingolipid 8-(E)-desaturase
EC 1.14.19.19 sphingolipid 10-desaturase
EC 1.14.19.20 Δ7-sterol 5(6)-desaturase
EC 1.14.19.21 cholesterol 7-desaturase
EC 1.14.19.22 acyl-lipid ω-6 desaturase (cytochrome b5)
EC 1.14.19.23 acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
EC 1.14.19.24 acyl-CoA 11-(E)-desaturase
EC 1.14.19.25 acyl-lipid ω-3 desaturase (cytochrome b5)
EC 1.14.19.26 acyl-[acyl-carrier-protein] 6-desaturase
EC 1.14.19.27 sn-2 palmitoyl-lipid 9-desaturase
EC 1.14.19.28 sn-1 stearoyl-lipid 9-desaturase
EC 1.14.19.29 sphingolipid 8-(E/Z)-desaturase
EC 1.14.19.30 acyl-lipid (8-3)-desaturase
EC 1.14.19.31 acyl-lipid (7-3)-desaturase
EC 1.14.19.32 palmitoyl-CoA 14-(E/Z)-desaturase
EC 1.14.19.33 Δ12 acyl-lipid conjugase (11E,13E-forming)
EC 1.14.19.34 acyl-lipid (9+3)-(E)-desaturase
EC 1.14.19.35 sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
EC 1.14.19.36 sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
EC 1.14.19.37 acyl-CoA 5-desaturase
EC 1.14.19.38 acyl-lipid Δ6-acetylenase
EC 1.14.19.39 acyl-lipid Δ12-acetylenase
EC 1.14.19.40 hex-5-enoyl-[acyl-carrier protein] acetylenase
EC 1.14.19.41 sterol 22-desaturase
EC 1.14.19.42 palmitoyl-[glycerolipid] 7-desaturase
EC 1.14.19.43 palmitoyl-[glycerolipid] 3-(E)-desaturase
EC 1.14.19.44 acyl-CoA (8-3)-desaturase
EC 1.14.19.45 sn-1 oleoyl-lipid 12-desaturase
EC 1.14.19.46 sn-1 linoleoyl-lipid 6-desaturase
EC 1.14.19.47 acyl-lipid (9-3)-desaturase
EC 1.14.21.6 transferred now EC 1.14.19.20
EC 1.14.99.3 transferred now EC 1.14.14.18
EC 1.14.99.9 transferred now EC 1.14.14.19
EC 1.14.99.10 transferred now EC 1.14.14.16
EC 1.14.99.31 transferred now EC 1.14.19.24
EC 1.14.99.32 transferred now EC 1.14.19.5
EC 1.14.99.33 transferred now EC 1.14.19.39
EC 1.14.99.36 transferred now 1.13.11.63
EC 1.14.99.50 γ-glutamyl hercynylcysteine S-oxide synthase
EC 1.14.99.51 hercynylcysteine S-oxide synthase
EC 1.14.99.52 L-cysteinyl-L-histidinylsulfoxide synthase
*EC 1.17.99.1 4-methylphenol dehydrogenase (hydroxylating)
EC 1.18.1.8 ferredoxin-NAD+ oxidoreductase (Na+-transporting)
*EC 1.20.4.1 arsenate reductase (glutaredoxin)
EC 1.20.4.4 arsenate reductase (thioredoxin)
EC 1.21.1 With NAD+ or NADP+ as acceptor
EC 1.21.1.2 2,4-dichlorobenzoyl-CoA reductase
EC 1.21.99.3 thyroxine 5-deiodinase
EC 1.21.99.4 thyroxine 5'-deiodinase
EC 1.22.1.1 transferred now EC 1.21.1.1
EC 1.23 Reducing C-O-C group as acceptor
EC 1.23.5.1 violaxanthin de-epoxidase
EC 1.97.1.10 transferred now EC 1.21.99.4
EC 1.97.1.11 transferred now EC 1.21.99.3
*EC 2.1.1.98 diphthine synthase
EC 2.1.1.124 deleted covered by EC 2.1.1.319, EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322
EC 2.1.1.125 deleted covered by EC 2.1.1.319, EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322
EC 2.1.1.126 deleted covered by EC 2.1.1.319, EC 2.1.1.320, EC 2.1.1.321 and EC 2.1.1.322
EC 2.1.1.314 diphthine methyl ester synthase
EC 2.1.1.315 27-O-demethylrifamycin SV methyltransferase
EC 2.1.1.316 mitomycin 6-O-methyltransferase
EC 2.1.1.317 sphingolipid C9-methyltransferase
EC 2.1.1.318 [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase
EC 2.1.1.319 type I protein arginine methyltransferase
EC 2.1.1.320 type II protein arginine methyltransferase
EC 2.1.1.321 type III protein arginine methyltransferase
EC 2.1.1.322 type IV protein arginine methyltransferase
*EC 2.3.1.60 gentamicin 3-N-acetyltransferase
*EC 2.3.1.81 aminoglycoside 3-N-acetyltransferase
EC 2.3.1.154 transferred now EC 2.3.1.176
EC 2.3.1.251 lipid IVA palmitoyltransferase
*EC 2.3.1.82 aminoglycoside 6'-N-acetyltransferase
EC 2.3.1.119 deleted now covered by EC 2.3.1.199, EC 1.1.1.330 and EC 4.2.1.134
*EC 2.3.1.161 lovastatin nonaketide synthase
*EC 2.3.1.169 CO-methylating acetyl-CoA synthase
EC 2.3.1.244 2-methylbutanoate polyketide synthase
EC 2.3.1.245 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
EC 2.3.1.246 3,5-dihydroxyphenylacetyl-CoA synthase
EC 2.3.1.247 3-keto-5-aminohexanoate cleavage enzyme
EC 2.3.1.248 spermidine disinapoyl transferase
EC 2.3.1.249 spermidine dicoumaroyl transferase
EC 2.3.1.250 [Wnt protein] O-palmitoleoyl transferase
EC 2.3.2.23 E2 ubiquitin-conjugating enzyme
EC 2.3.2.24 (E3-independent) E2 ubiquitin-conjugating enzyme
EC 2.3.2.25 N-terminal E2 ubiquitin-conjugating enzyme
EC 2.3.2.26 HECT-type E3 ubiquitin transferase
EC 2.3.2.27 RING-type E3 ubiquitin transferase
EC 2.3.2.28 L-allo-isoleucyltransferase
*EC 2.3.3.5 2-methylcitrate synthase
*EC 2.4.1.33 mannuronan synthase
*EC 2.4.1.147 acetylgalactosaminyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase
*EC 2.4.1.153 UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminyltransferase
EC 2.4.1.157 transferred now EC 2.4.1.336 and EC 2.4.1.337
*EC 2.4.1.159 flavonol-3-O-glucoside L-rhamnosyltransferase
*EC 2.4.1.184 galactolipid galactosyltransferase
*EC 2.4.1.213 glucosylglycerol-phosphate synthase
*EC 2.4.1.326 aklavinone 7-L-rhodosaminyltransferase
EC 2.4.1.335 dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase
EC 2.4.1.336 monoglucosyldiacylglycerol synthase
EC 2.4.1.337 1,2-diacylglycerol 3-α-glucosyltransferase
*EC 2.4.2.37 NAD+—dinitrogen-reductase ADP-D-ribosyltransferase
*EC 2.4.2.54 β-ribofuranosylhydroxybenzene 5'-phosphate synthase
EC 2.4.99.21 dolichyl-phosphooligosaccharide-protein glycotransferase
*EC 2.5.1.3 thiamine phosphate synthase
*EC 2.5.1.15 dihydropteroate synthase
EC 2.5.1.129 flavin prenyltransferase
EC 2.5.1.130 2-carboxy-1,4-naphthoquinone phytyltransferase
EC 2.5.1.131 (4-{4-[2-(γ-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
EC 2.6.1.108 (5-formylfuran-3-yl)methyl phosphate transaminase
EC 2.6.1.109 8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase
EC 2.7.1.187 acarbose 7IV-phosphotransferase
EC 2.7.1.188 2-epi-5-epi-valiolone 7-kinase
EC 2.7.1.189 autoinducer-2 kinase
EC 2.7.1.190 aminoglycoside 2''-phosphotransferase
EC 2.7.4.29 Kdo2-lipid A phosphotransferase
EC 2.7.4.30 lipid A phosphoethanolamine transferase
EC 2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
*EC 2.7.6.3 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
EC 2.7.7.88 GDP polyribonucleotidyltransferase
EC 2.7.7.89 [glutamate—ammonia ligase]-adenylyl-L-tyrosine phosphorylase
*EC 2.8.1.9 molybdenum cofactor sulfurtransferase
EC 2.7.8.42 Kdo2-lipid A phosphoethanolamine 7''-transferase
EC 2.8.1.13 tRNA-uridine 2-sulfurtransferase
EC 2.8.1.14 tRNA-5-taurinomethyluridine 2-sulfurtransferase
EC 2.8.3.23 caffeate CoA-transferase
*EC 2.8.4.3 tRNA-2-methylthio-N6-dimethylallyladenosine synthase
*EC 2.8.4.5 tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase
*EC 3.1.1.59 juvenile-hormone esterase
*EC 3.1.1.97 methylated diphthine methylhydrolase
EC 3.1.1.98 [Wnt protein] O-palmitoleoyl-L-serine hydrolase
EC 3.1.2.31 dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
*EC 3.1.3.69 glucosylglycerol 3-phosphatase
EC 3.1.3.97 3',5'-nucleoside bisphosphate phosphatase
EC 3.1.3.98 geranyl diphosphate phosphohydrolase
EC 3.1.4.15 transferred now EC 2.7.7.89
EC 3.3.2.14 2,4-dinitroanisole O-demethylase
EC 3.4.14.13 γ-D-glutamyl-L-lysine dipeptidyl-peptidase
EC 3.4.24.88 desampylase
EC 3.4.24.89 Pro-Pro endopeptidase
EC 3.5.1.118 γ-glutamyl hercynylcysteine S-oxide hydrolase
EC 3.5.1.119 Pup deamidase
*EC 4.1.1.98 4-hydroxy-3-polyprenylbenzoate decarboxylase
EC 4.1.1.100 prephenate decarboxylase
EC 4.1.1.101 malolactic enzyme
EC 4.1.1.102 phenacrylate decarboxylase
*EC 4.1.2.25 dihydroneopterin aldolase
*EC 4.1.2.44 2,3-epoxybenzoyl-CoA dihydrolase
EC 4.1.99.21 (5-formylfuran-3-yl)methyl phosphate synthase
EC 4.1.99.21 transferred now EC 4.2.3.154
*EC 4.2.1.42 galactarate dehydratase
EC 4.2.1.155 methylthioacryloyl-CoA hydratase
EC 4.2.1.156 L-talarate dehydratase
EC 4.2.1.157 (R)-2-hydroxyisocaproyl-CoA dehydratase
EC 4.2.1.158 galactarate dehydratase (D-threo-forming)
EC 4.2.1.159 dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase
EC 4.2.1.160 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
EC 4.2.1.161 bisanhydrobacterioruberin hydratase
*EC 4.2.2.3 mannuronate-specific alginate lyase
*EC 4.2.2.11 guluronate-specific alginate lyase
EC 4.2.2.26 oligo-alginate lyase
EC 4.2.3.152 2-epi-5-epi-valiolone synthase
EC 4.2.3.153 (5-formylfuran-3-yl)methyl phosphate synthase
EC 4.4.1.29 phycobiliprotein cysteine-84 phycobilin lyase
EC 4.4.1.30 phycobiliprotein β-cysteine-155 phycobilin lyase
EC 4.4.1.31 phycoerythrocyanin α-cysteine-84 phycoviolobilin lyase/isomerase
EC 4.4.1.32 C-phycocyanin α-cysteine-84 phycocyanobilin lyase
EC 4.4.1.33 R-phycocyanin α-cysteine-84 phycourobilin lyase/isomerase
EC 5.1.1.20 L-Ala-D/L-Glu epimerase
EC 5.1.1.21 isoleucine 2-epimerase
*EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase
EC 5.1.3.33 2-epi-5-epi-valiolone epimerase
EC 5.1.3.34 monoglucosyldiacylglycerol epimerase
EC 5.1.3.35 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
EC 5.1.3.36 heparosan-glucuronate 5-epimerase
EC 5.1.3.37 mannuronan 5-epimerase
EC 5.1.99.7 dihydroneopterin triphosphate 2'-epimerase
EC 5.1.99.8 7,8-dihydroneopterin epimerase
EC 5.3.1.32 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
EC 5.3.3.19 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
EC 5.4.1.4 D-galactarolactone isomerase
EC 5.4.99.63 ethylmalonyl-CoA mutase
*EC 5.5.1.25 3,6-anhydro-L-galactonate cycloisomerase
EC 5.5.1.26 nogalonic acid methyl ester cyclase
EC 5.5.1.27 D-galactarolactone cycloisomerase
EC 6.2.1.45 E1 ubiquitin-activating enzyme
EC 6.2.1.46 L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase
EC 6.3.1.19 prokaryotic ubiquitin-like protein ligase
EC 6.3.2.19 deleted now covered by EC 6.2.1.45, EC 2.3.2.23 and EC 2.3.2.27
EC 6.3.2.21 deleted now covered by EC 6.2.1.45 and EC 2.3.2.27
EC 6.3.2.28 transferred now EC 6.3.2.49
*EC 6.3.2.37 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
EC 6.3.2.46 fumarate—(S)-2,3-diaminopropanoate ligase
EC 6.3.2.47 dapdiamide A synthase
EC 6.3.2.48 L-arginine-specific L-amino acid ligase
EC 6.3.2.49 L-alanine-L-anticapsin ligase
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