Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

Supplement 21 (2015)

The following documents with additions and amendments to Enzyme Nomenclature have been approved after public review:

New enzymes (30 April 2015, approved 28 May 2015)
New enzymes (21 August 2015, approved 17 September 2015)
New enzymes (10 November 2015, approved 7 December 2015)
The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.


*EC glucose-6-phosphate dehydrogenase (NADP+)
*EC ketol-acid reductoisomerase (NADP+)
*EC serine 3-dehydrogenase (NADP+)
*EC glucose-6-phosphate dehydrogenase [NAD(P)+]
*EC 3-hydroxy acid dehydrogenase
EC ketol-acid reductoisomerase (NAD+)
EC ketol-acid reductoisomerase [NAD(P)+]
EC dTDP-3,4-didehydro-2,6-dideoxy-α-D-glucose 3-reductase
EC dihydroanticapsin dehydrogenase
EC ipsdienol dehydrogenase
EC L-serine 3-dehydrogenase (NAD+)
EC glucose-6-phosphate dehydrogenase (NAD+)
EC 2-dehydro-3-deoxy-L-galactonate 5-dehydrogenase
EC sulfoquinovose 1-dehydrogenase
EC 3-deoxy-α-D-manno-octulosonate 8-oxidase
*EC 4-hydroxybenzaldehyde dehydrogenase (NAD+)
EC formate dehydrogenase (NAD+, ferredoxin)
EC farnesal dehydrogenase
EC L-2-aminoadipate reductase
EC 4-hydroxybenzaldehyde dehydrogenase (NADP+)
EC 3-sulfolactaldehyde dehydrogenase
EC aldehyde dehydrogenase (quinone)
EC 1.2.98 With other, known, physiological acceptors

EC formaldehyde dismutase
EC transferred now EC
EC transferred now EC
EC transferred now EC
*EC arogenate dehydrogenase
EC transferred now EC
EC caffeoyl-CoA reductase
EC butanoyl-CoA dehydrogenase (NAD+, ferredoxin)
EC lactate dehydrogenase (NAD+, ferredoxin)
EC 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase
EC (2S)-methylsuccinyl-CoA dehydrogenase
EC transferred now EC
EC 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase
EC transferred now EC
EC D-arginine dehydrogenase
*EC 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
*EC 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
EC 1-pyrroline-2-carboxylate reductase [NAD(P)H]
EC dihydromonapterin reductase
*EC (S)-6-hydroxynicotine oxidase
*EC (R)-6-hydroxynicotine oxidase
EC NAD(P)+ transhydrogenase (ferredoxin)
EC proton-translocating NAD(P)+ transhydrogenase
*EC renalase
EC NADH dehydrogenase (quinone)
EC demethylphylloquinone reductase
EC transferred now EC
*EC hydroxylamine oxidase (cytochrome)
*EC assimilatory sulfite reductase (NADPH)
*EC assimilatory sulfite reductase (ferredoxin)
EC deleted now covered by EC and EC
EC dissimilatory sulfite reductase
EC 1.10.5 With a quinone or related compound as acceptor
EC ribosyldihydronicotinamide dehydrogenase (quinone)
EC transferred now EC
EC transferred now EC
*EC phospholipid-hydroperoxide glutathione peroxidase
*EC dye decolorizing peroxidase
*EC persulfide dioxygenase
EC (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
EC 7,8-dihydroneopterin oxygenase
EC 8'-apo-carotenoid 13,14-cleaving dioxygenase
EC deoxynogalonate monooxygenase
EC xanthine dioxygenase
EC uridine-5'-phosphate dioxygenase
EC transferred now EC
EC nitroarene dioxygenase
EC 2,4-dinitrotoluene dioxygenase
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now EC
*EC ferruginol synthase
EC β-amyrin 28-monooxygenase
EC methyl farnesoate epoxidase
EC farnesoate epoxidase
EC long-chain acyl-CoA ω-monooxygenase
EC long-chain fatty acid ω-monooxygenase
EC laurate 7-monooxygenase
EC ipsdienol synthase
EC benzoyl-CoA 2,3-epoxidase
EC salicyloyl-CoA 5-hydroxylase
*EC unspecific monooxygenase
EC steroid 21-monooxygenase
EC squalene monooxygenase
EC heme oxygenase (biliverdin-producing)
EC steroid 17α-monooxygenase
EC methyl-branched lipid ω-hydroxylase
EC phosphatidylcholine 12-monooxygenase
EC sphingolipid C4-monooxygenase
EC 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase
EC dihydroceramide fatty acyl 2-hydroxylase
EC 7α-hydroxycholest-4-en-3-one 12α-hydroxylase
*EC stearoyl-[acyl-carrier-protein] 9-desaturase
*EC acyl-CoA 6-desaturase
*EC acyl-lipid (11-3)-desaturase
*EC acyl-CoA 11-(Z)-desaturase
*EC acyl-CoA (9+3)-desaturase
EC icosanoyl-CoA 5-desaturase
EC palmitoyl-[acyl-carrier-protein] 4-desaturase
EC acyl-lipid ω-(9-4) desaturase
EC acyl-CoA 15-desaturase
EC linoleoyl-lipid Δ9 conjugase
EC (11Z)-hexadec-11-enoyl-CoA conjugase
EC linoleoyl-lipid Δ12 conjugase (11E,13Z-forming)
EC sphingolipid 4-desaturase
EC sphingolipid 8-(E)-desaturase
EC sphingolipid 10-desaturase
EC Δ7-sterol 5(6)-desaturase
EC cholesterol 7-desaturase
EC acyl-lipid ω-6 desaturase (cytochrome b5)
EC acyl-lipid (n+3)-(Z)-desaturase (ferredoxin)
EC acyl-CoA 11-(E)-desaturase
EC acyl-lipid ω-3 desaturase (cytochrome b5)
EC acyl-[acyl-carrier-protein] 6-desaturase
EC sn-2 palmitoyl-lipid 9-desaturase
EC sn-1 stearoyl-lipid 9-desaturase
EC sphingolipid 8-(E/Z)-desaturase
EC acyl-lipid (8-3)-desaturase
EC acyl-lipid (7-3)-desaturase
EC palmitoyl-CoA 14-(E/Z)-desaturase
EC Δ12 acyl-lipid conjugase (11E,13E-forming)
EC acyl-lipid (9+3)-(E)-desaturase
EC sn-2 acyl-lipid ω-3 desaturase (ferredoxin)
EC sn-1 acyl-lipid ω-3 desaturase (ferredoxin)
EC acyl-CoA 5-desaturase
EC acyl-lipid Δ6-acetylenase
EC acyl-lipid Δ12-acetylenase
EC hex-5-enoyl-[acyl-carrier protein] acetylenase
EC sterol 22-desaturase
EC palmitoyl-[glycerolipid] 7-desaturase
EC palmitoyl-[glycerolipid] 3-(E)-desaturase
EC acyl-CoA (8-3)-desaturase
EC sn-1 oleoyl-lipid 12-desaturase
EC sn-1 linoleoyl-lipid 6-desaturase
EC acyl-lipid (9-3)-desaturase
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now EC
EC transferred now
EC γ-glutamyl hercynylcysteine S-oxide synthase
EC hercynylcysteine S-oxide synthase
EC L-cysteinyl-L-histidinylsulfoxide synthase
*EC 4-methylphenol dehydrogenase (hydroxylating)
EC ferredoxin-NAD+ oxidoreductase (Na+-transporting)
*EC arsenate reductase (glutaredoxin)
EC arsenate reductase (thioredoxin)
EC 1.21.1 With NAD+ or NADP+ as acceptor

EC iodotyrosine deiodinase
EC 2,4-dichlorobenzoyl-CoA reductase
EC thyroxine 5-deiodinase
EC thyroxine 5'-deiodinase
EC transferred now EC
EC 1.23 Reducing C-O-C group as acceptor
EC violaxanthin de-epoxidase
EC transferred now EC
EC transferred now EC
*EC diphthine synthase
EC deleted covered by EC, EC, EC and EC
EC deleted covered by EC, EC, EC and EC
EC deleted covered by EC, EC, EC and EC
EC diphthine methyl ester synthase
EC 27-O-demethylrifamycin SV methyltransferase
EC mitomycin 6-O-methyltransferase
EC sphingolipid C9-methyltransferase
EC [trehalose-6-phosphate synthase]-L-cysteine S-methyltransferase
EC type I protein arginine methyltransferase
EC type II protein arginine methyltransferase
EC type III protein arginine methyltransferase
EC type IV protein arginine methyltransferase
*EC gentamicin 3-N-acetyltransferase
*EC aminoglycoside 3-N-acetyltransferase
EC transferred now EC
EC lipid IVA palmitoyltransferase
*EC aminoglycoside 6'-N-acetyltransferase
EC deleted now covered by EC, EC and EC
*EC lovastatin nonaketide synthase
*EC CO-methylating acetyl-CoA synthase
EC 2-methylbutanoate polyketide synthase
EC 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
EC 3,5-dihydroxyphenylacetyl-CoA synthase
EC 3-keto-5-aminohexanoate cleavage enzyme
EC spermidine disinapoyl transferase
EC spermidine dicoumaroyl transferase
EC [Wnt protein] O-palmitoleoyl transferase
EC E2 ubiquitin-conjugating enzyme
EC (E3-independent) E2 ubiquitin-conjugating enzyme
EC N-terminal E2 ubiquitin-conjugating enzyme
EC HECT-type E3 ubiquitin transferase
EC RING-type E3 ubiquitin transferase
EC L-allo-isoleucyltransferase
*EC 2-methylcitrate synthase
*EC mannuronan synthase
*EC acetylgalactosaminyl-O-glycosyl-glycoprotein β-1,3-N-acetylglucosaminyltransferase
*EC UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminyltransferase
EC transferred now EC and EC
*EC flavonol-3-O-glucoside L-rhamnosyltransferase
*EC galactolipid galactosyltransferase
*EC glucosylglycerol-phosphate synthase
*EC aklavinone 7-L-rhodosaminyltransferase
EC dolichyl N-acetyl-α-D-glucosaminyl phosphate 3-β-D-2,3-diacetamido-2,3-dideoxy-β-D-glucuronosyltransferase
EC monoglucosyldiacylglycerol synthase
EC 1,2-diacylglycerol 3-α-glucosyltransferase
*EC NAD+—dinitrogen-reductase ADP-D-ribosyltransferase
*EC β-ribofuranosylhydroxybenzene 5'-phosphate synthase
EC dolichyl-phosphooligosaccharide-protein glycotransferase
*EC thiamine phosphate synthase
*EC dihydropteroate synthase
EC flavin prenyltransferase
EC 2-carboxy-1,4-naphthoquinone phytyltransferase
EC (4-{4-[2-(γ-L-glutamylamino)ethyl]phenoxymethyl}furan-2-yl)methanamine synthase
EC (5-formylfuran-3-yl)methyl phosphate transaminase
EC 8-amino-3,8-dideoxy-α-D-manno-octulosonate transaminase
EC acarbose 7IV-phosphotransferase
EC 2-epi-5-epi-valiolone 7-kinase
EC autoinducer-2 kinase
EC aminoglycoside 2''-phosphotransferase
EC Kdo2-lipid A phosphotransferase
EC lipid A phosphoethanolamine transferase
EC [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
*EC 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
EC GDP polyribonucleotidyltransferase
EC [glutamate—ammonia ligase]-adenylyl-L-tyrosine phosphorylase
*EC molybdenum cofactor sulfurtransferase
EC Kdo2-lipid A phosphoethanolamine 7''-transferase
EC tRNA-uridine 2-sulfurtransferase
EC tRNA-5-taurinomethyluridine 2-sulfurtransferase
EC caffeate CoA-transferase
*EC tRNA-2-methylthio-N6-dimethylallyladenosine synthase
*EC tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase
*EC juvenile-hormone esterase
*EC methylated diphthine methylhydrolase
EC [Wnt protein] O-palmitoleoyl-L-serine hydrolase
EC dihydromonacolin L-[lovastatin nonaketide synthase] thioesterase
*EC glucosylglycerol 3-phosphatase
EC 3',5'-nucleoside bisphosphate phosphatase
EC geranyl diphosphate phosphohydrolase
EC transferred now EC
EC 2,4-dinitroanisole O-demethylase
EC γ-D-glutamyl-L-lysine dipeptidyl-peptidase
EC desampylase
EC Pro-Pro endopeptidase
EC γ-glutamyl hercynylcysteine S-oxide hydrolase
EC Pup deamidase
*EC 4-hydroxy-3-polyprenylbenzoate decarboxylase
EC prephenate decarboxylase
EC malolactic enzyme
EC phenacrylate decarboxylase
*EC dihydroneopterin aldolase
*EC 2,3-epoxybenzoyl-CoA dihydrolase
EC (5-formylfuran-3-yl)methyl phosphate synthase
EC transferred now EC
*EC galactarate dehydratase
EC methylthioacryloyl-CoA hydratase
EC L-talarate dehydratase
EC (R)-2-hydroxyisocaproyl-CoA dehydratase
EC galactarate dehydratase (D-threo-forming)
EC dTDP-4-dehydro-6-deoxy-α-D-glucopyranose 2,3-dehydratase
EC 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase
EC bisanhydrobacterioruberin hydratase
*EC mannuronate-specific alginate lyase
*EC guluronate-specific alginate lyase
EC oligo-alginate lyase
EC 2-epi-5-epi-valiolone synthase
EC (5-formylfuran-3-yl)methyl phosphate synthase
EC phycobiliprotein cysteine-84 phycobilin lyase
EC phycobiliprotein β-cysteine-155 phycobilin lyase
EC phycoerythrocyanin α-cysteine-84 phycoviolobilin lyase/isomerase
EC C-phycocyanin α-cysteine-84 phycocyanobilin lyase
EC R-phycocyanin α-cysteine-84 phycourobilin lyase/isomerase
EC L-Ala-D/L-Glu epimerase
EC isoleucine 2-epimerase
*EC heparosan-N-sulfate-glucuronate 5-epimerase
EC 2-epi-5-epi-valiolone epimerase
EC monoglucosyldiacylglycerol epimerase
EC 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
EC heparosan-glucuronate 5-epimerase
EC mannuronan 5-epimerase
EC dihydroneopterin triphosphate 2'-epimerase
EC 7,8-dihydroneopterin epimerase
EC (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
EC 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate isomerase
EC D-galactarolactone isomerase
EC ethylmalonyl-CoA mutase
*EC 3,6-anhydro-L-galactonate cycloisomerase
EC nogalonic acid methyl ester cyclase
EC D-galactarolactone cycloisomerase
EC E1 ubiquitin-activating enzyme
EC L-allo-isoleucine:holo-[CmaA peptidyl-carrier protein] ligase
EC prokaryotic ubiquitin-like protein ligase
EC deleted now covered by EC, EC and EC
EC deleted now covered by EC and EC
EC transferred now EC
*EC UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—D-lysine ligase
EC fumarate—(S)-2,3-diaminopropanoate ligase
EC dapdiamide A synthase
EC L-arginine-specific L-amino acid ligase
EC L-alanine-L-anticapsin ligase

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