New enzymes (27 February 2019, approved 27 March 2019)The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (20 May 2019, approved 14 June 2019)
New enzymes (23 July 2019, approved 20 August 2019)
New enzymes (4 October 2019, approved 1 November 2019)
New enzymes (5 December 2019, approved 2 January 2020)
*EC 1.1.1.21 aldose reductase (5 December 2019)
*EC 1.1.1.170 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) (20 May 2019)
EC 1.1.1.417 3β-hydroxysteroid-4β-carboxylate 3-dehydrogenase (decarboxylating) (20 May 2019)
EC 1.1.1.418 plant 3β-hydroxysteroid-4α-carboxylate 3-dehydrogenase (decarboxylating) (20 May 2019)
EC 1.1.1.419 nepetalactol dehydrogenase (4 October 2019)
EC 1.1.1.420 D-apiose dehydrogenase (5 December 2019)
EC 1.1.1.421 D-apionate oxidoisomerase (5 December 2019)
EC 1.1.2.10 lanthanide-dependent methanol dehydrogenase (5 December 2019)
EC 1.1.5.13 (S)-2-hydroxyglutarate dehydrogenase (4 October 2019)
*EC 1.2.1.25 branched-chain α-keto acid dehydrogenase system (5 December 2019)
*EC 1.2.1.30 carboxylate reductase (NADP+) (27 February 2019)
EC 1.2.1.103 [amino group carrier protein]-6-phospho-L-2-aminoadipate reductase (5 December 2019)
EC 1.3.1.99 deleted, now known to be catalyzed by EC 1.3.1.122 and EC 5.5.1.34 (5 December 2019)
EC 1.3.1.120 cyclohexane-1-carbonyl-CoA reductase (NADP+) (23 July 2019)
EC 1.3.1.121 4-amino-4-deoxyprephenate dehydrogenase (5 December 2019)
EC 1.3.1.122 (S)-8-oxocitronellyl enol synthase (5 December 2019)
EC 1.3.1.123 7-epi-iridoid synthase (5 December 2019)
*EC 1.3.8.6 glutaryl-CoA dehydrogenase (ETF) (27 February 2019)
EC 1.3.8.15 3-(aryl)acrylate reductase (5 December 2019)
EC 1.3.98.5 hydrogen peroxide-dependent heme synthase (23 July 2019)
EC 1.3.98.6 AdoMet-dependent heme synthase (23 July 2019)
*EC 1.4.1.14 glutamate synthase (NADH) (27 February 2019)
*EC 1.6.5.9 NADH:quinone reductase (non-electrogenic) (5 December 2019)
EC 1.6.5.11 deleted, identical to EC 1.6.5.9 (5 December 2019)
EC 1.8.1.21 dissimilatory dimethyldisulfide reductase (23 July 2019)
EC 1.8.4.15 protein dithiol oxidoreductase (disulfide-forming) (5 December 2019)
EC 1.8.4.16 thioredoxin:protein disulfide reductase (5 December 2019)
*EC 1.8.5.3 respiratory dimethylsulfoxide reductase (27 February 2019)
EC 1.8.5.9 protein dithiol:quinone oxidoreductase DsbB (5 December 2019)
EC 1.9.3.1 transferred, now EC 7.1.1.9 (5 December 2019)
EC 1.10.3.17 superoxide oxidase (5 December 2019)
*EC 1.13.11.79 aerobic 5,6-dimethylbenzimidazole synthase (5 December 2019)
EC 1.13.11.88 isoeugenol monooxygenase (27 February 2019)
EC 1.13.11.89 hydroxymethylphosphonate dioxygenase (23 July 2019)
*EC 1.14.11.27 [histone H3]-dimethyl-L-lysine36 demethylase (23 July 2019)
EC 1.14.11.61 feruloyl-CoA 6-hydroxylase (27 February 2019)
EC 1.14.11.62 trans-4-coumaroyl-CoA 2-hydroxylase (27 February 2019)
EC 1.14.11.63 peptidyl-lysine (3S)-dioxygenase (27 February 2019)
EC 1.14.11.64 glutarate dioxygenase (23 July 2019)
EC 1.14.11.65 [histone H3]-dimethyl-L-lysine9 demethylase (23 July 2019)
EC 1.14.11.66 [histone H3]-trimethyl-L-lysine9 demethylase (23 July 2019)
EC 1.14.11.67 [histone H3]-trimethyl-L-lysine4 demethylase (23 July 2019)
EC 1.14.11.68 [histone H3]-trimethyl-L-lysine27 demethylase (23 July 2019)
EC 1.14.11.69 [histone H3]-trimethyl-L-lysine36 demethylase (23 July 2019)
EC 1.14.11.70 7-deoxycylindrospermopsin hydroxylase (5 December 2019)
EC 1.14.11.71 methylphosphonate hydroxylase (5 December 2019)
EC 1.14.13.243 toluene 2-monooxygenase (27 February 2019)
EC 1.14.13.244 phenol 2-monooxygenase (NADH) (27 February 2019)
EC 1.14.13.245 assimilatory dimethylsulfide S-monooxygenase (27 February 2019)
EC 1.14.13.246 4β-methylsterol monooxygenase (20 May 2019)
EC 1.14.13.247 stachydrine N-demethylase (5 December 2019)
*EC 1.14.14.22 dibenzothiophene sulfone monooxygenase (5 December 2019)
EC 1.14.14.171 β-amyrin 16α-hydroxylase (20 May 2019)
EC 1.14.15.36 sterol 14α-demethylase (ferredoxin) (27 February 2019)
EC 1.14.15.37 luteothin monooxygenase (27 February 2019)
*EC 1.14.16.1 phenylalanine 4-monooxygenase (5 December 2019)
*EC 1.14.16.2 tyrosine 3-monooxygenase (5 December 2019)
*EC 1.14.16.4 tryptophan 5-monooxygenase (5 December 2019)
*EC 1.14.16.7 phenylalanine 3-monooxygenase (5 December 2019)
*EC 1.14.17.3 peptidylglycine monooxygenase (5 December 2019)
*EC 1.14.18.9 4α-methylsterol monooxygenase (20 May 2019)
EC 1.14.18.10 plant 4,4-dimethylsterol C-4α-methyl-monooxygenase (20 May 2019)
EC 1.14.18.11 plant 4α-monomethylsterol monooxygenase (20 May 2019)
*EC 1.14.99.46 pyrimidine oxygenase (5 December 2019)
EC 1.14.99.65 4-amino-L-phenylalanyl-[CmlP-peptidyl-carrier-protein] 3-hydroxylase (27 February 2019)
EC 1.14.99.66 [histone-H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase (23 July 2019)
EC 1.16.8.1 deleted, now known to be catalysed by EC 2.5.1.17 (5 December 2019)
*EC 1.20.4.1 arsenate reductase (glutaredoxin) (20 May 2019)
*EC 1.20.4.4 arsenate reductase (thioredoxin) (20 May 2019)
EC 2.1.1.43 transferred now EC 2.1.1.354, EC 2.1.1.355, EC 2.1.1.356, EC 2.1.1.357, EC 2.1.1.358, EC 2.1.1.359, EC 2.1.1.360, EC 2.1.1.361 and EC 2.1.1.362 (23 July 2019)
*EC 2.1.1.74 methylenetetrahydrofolate—tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing] (5 December 2019)
*EC 2.1.1.95 tocopherol C-methyltransferase (23 July 2019)
*EC 2.1.1.142 cycloartenol 24-C-methyltransferase (23 July 2019)
*EC 2.1.1.308 cytidylyl-2-hydroxyethylphosphonate methyltransferase (4 October 2019)
EC 2.1.1.353 demethylluteothin O-methyltransferase (27 February 2019)
EC 2.1.1.354 histone H3 lysine4 N-trimethyltransferase (23 July 2019)
EC 2.1.1.355 histone H3 lysine9 N-trimethyltransferase (23 July 2019)
EC 2.1.1.356 histone H3 lysine27 N-trimethyltransferase (23 July 2019)
EC 2.1.1.357 histone H3 lysine36 N-dimethyltransferase (23 July 2019)
EC 2.1.1.358 histone H3 dimethyl-L-lysine36 N-methyltransferase (23 July 2019)
EC 2.1.1.359 histone H3 lysine36 N-trimethyltransferase (23 July 2019)
EC 2.1.1.360 histone H3 lysine79 N-trimethyltransferase (23 July 2019)
EC 2.1.1.361 histone H4 lysine20 N-methyltransferase (23 July 2019)
EC 2.1.1.362 histone H4 N-methyl-L-lysine20 N-methyltransferase (23 July 2019)
EC 2.1.1.363 pre-sodorifen synthase (5 December 2019)
EC 2.1.4.3 L-arginine:L-lysine amidinotransferase (4 October 2019)
*EC 2.3.1.9 acetyl-CoA C-acetyltransferase (20 May 2019)
*EC 2.3.1.16 acetyl-CoA C-acyltransferase (20 May 2019)
*EC 2.3.1.26 sterol O-acyltransferase (4 October 2019)
*EC 2.3.1.85 fatty-acid synthase system (27 February 2019)
*EC 2.3.1.86 fatty-acyl-CoA synthase system (27 February 2019)
*EC 2.3.1.161 lovastatin nonaketide synthase (27 February 2019)
*EC 2.3.1.252 mycolipanoate synthase (4 October 2019)
EC 2.3.1.281 5-hydroxydodecatetraenal polyketide synthase (27 February 2019)
EC 2.3.1.282 phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase (27 February 2019)
EC 2.3.1.283 2'-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase (27 February 2019)
EC 2.3.1.284 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase (27 February 2019)
EC 2.3.1.285 (13S,14R)-1,13-dihydroxy-N-methylcanadine 13-O-acetyltransferase (27 February 2019)
EC 2.3.1.286 protein acetyllysine N-acetyltransferase (20 May 2019)
EC 2.3.1.287 phthioceranic/hydroxyphthioceranic acid synthase (20 May 2019)
EC 2.3.1.288 2-O-sulfo trehalose long-chain-acyltransferase (23 July 2019)
EC 2.3.1.289 aureothin polyketide synthase system (23 July 2019)
EC 2.3.1.290 spectinabilin polyketide synthase system (23 July 2019)
EC 2.3.1.291 sphingoid base N-palmitoyltransferase (23 July 2019)
*EC 2.3.1.291 sphingoid base N-palmitoyltransferase (5 December 2019)
EC 2.3.1.292 (phenol)carboxyphthiodiolenone synthase (4 October 2019)
EC 2.3.1.293 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I (4 October 2019)
EC 2.3.1.294 meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II (4 October 2019)
EC 2.3.1.295 mycoketide-CoA synthase (4 October 2019)
EC 2.3.1.296 ω-hydroxyceramide transacylase (4 October 2019)
EC 2.3.1.297 very-long-chain ceramide synthase (4 October 2019)
EC 2.3.1.298 ultra-long-chain ceramide synthase (4 October 2019)
EC 2.3.1.299 sphingoid base N-stearoyltransferase (4 October 2019)
EC 2.3.2.33 RCR-type E3 ubiquitin transferase (5 December 2019)
*EC 2.4.1.152 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase (23 July 2019)
EC 2.4.1.361 GDP-mannose:di-myo-inositol-1,3'-phosphate β-1,2-mannosyltransferase (27 February 2019)
EC 2.4.1.362 α-(1→3) branching sucrase (27 February 2019)
EC 2.4.1.363 ginsenoside 20-O-glucosyltransferase (20 May 2019)
EC 2.4.1.364 protopanaxadiol-type ginsenoside 3-O-glucosyltransferase (20 May 2019)
EC 2.4.1.365 protopanaxadiol-type ginsenoside-3-O-glucoside 2"-O-glucosyltransferase (20 May 2019)
EC 2.4.1.366 ginsenoside F1 6-O-glucosyltransferase (20 May 2019)
EC 2.4.1.367 ginsenoside 6-O-glucosyltransferase (20 May 2019)
EC 2.4.1.368 oleanolate 3-O-glucosyltransferase (20 May 2019)
EC 2.4.1.369 enterobactin C-glucosyltransferase (23 July 2019)
EC 2.4.1.370 inositol phosphorylceramide mannosyltransferase (23 July 2019)
EC 2.4.1.371 polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-α-mannosylpolymerase (5 December 2019)
EC 2.4.1.372 mutansucrase (5 December 2019)
EC 2.4.1.373 α-(1→2) branching sucrase (5 December 2019)
EC 2.4.1.374 β-1,2-mannooligosaccharide synthase (5 December 2019)
EC 2.5.1.152 D-histidine 2-aminobutanoyltransferase (27 February 2019)
EC 2.6.1.115 5-hydroxydodecatetraenal 1-aminotransferase (27 February 2019)
EC 2.6.1.116 6-aminohexanoate aminotransferase (4 October 2019)
EC 2.6.1.117 L-glutamine—4-(methylsulfanyl)-2-oxobutanoate aminotransferase (4 October 2019)
EC 2.6.1.118 [amino group carrier protein]-γ-(L-lysyl)-L-glutamate aminotransferase (5 December 2019)
EC 2.7.1.225 L-serine kinase (ATP) (27 February 2019)
EC 2.7.1.226 L-serine kinase (ADP) (27 February 2019)
EC 2.7.1.227 inositol phosphorylceramide synthase (4 October 2019)
EC 2.7.1.228 mannosyl-inositol-phosphoceramide inositolphosphotransferase (4 October 2019)
EC 2.7.1.229 deoxyribokinase (4 October 2019)
EC 2.7.1.230 amicoumacin kinase (5 December 2019)
EC 2.7.2.16 2-phosphoglycerate kinase (5 December 2019)
EC 2.8.1.16 L-aspartate semialdehyde sulfurtransferase (4 October 2019)
*EC 2.8.3.17 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase (4 October 2019)
*EC 3.1.1.96 D-aminoacyl-tRNA deacylase (4 October 2019)
EC 3.1.1.105 3-O-acetylpapaveroxine carboxylesterase (27 February 2019)
EC 3.1.1.106 O-acetyl-ADP-ribose deacetylase (20 May 2019)
EC 3.1.1.107 apo-salmochelin esterase (23 July 2019)
EC 3.1.1.108 ferric enterobactin esterase (23 July 2019)
EC 3.1.1.109 ferric salmochelin esterase (23 July 2019)
EC 3.1.1.110 xylono-1,5-lactonase (4 October 2019)
EC 3.1.1.111 phosphatidylserine sn-1 acylhydrolase (4 October 2019)
EC 3.1.1.112 isoamyl acetate esterase (4 October 2019)
EC 3.1.1.113 ethyl acetate hydrolase (4 October 2019)
EC 3.1.1.114 methyl acetate hydrolase (4 October 2019)
EC 3.1.3.106 2-lysophosphatidate phosphatase (23 July 2019)
EC 3.1.3.107 amicoumacin phosphatase (5 December 2019)
EC 3.1.4.59 cyclic-di-AMP phosphodiesterase (27 February 2019)
EC 3.1.4.60 pApA phosphodiesterase (27 February 2019)
EC 3.1.11.7 transferred, now EC 3.6.1.71 (5 December 2019)
EC 3.1.11.8 transferred, now EC 3.6.1.70 (5 December 2019)
EC 3.1.12.2 transferred, now EC 3.6.1.72 (5 December 2019)
EC 3.1.27.10 transferred now EC 4.6.1.23 (4 October 2019)
*EC 3.2.1.15 endo-polygalacturonase (27 February 2019)
*EC 3.2.1.67 galacturonan 1,4-α-galacturonidase (27 February 2019)
*EC 3.2.1.82 exo-poly-α-digalacturonosidase (27 February 2019)
*EC 3.2.1.113 mannosyl-oligosaccharide 1,2-α-mannosidase (4 October 2019)
EC 3.2.1.209 endoplasmic reticulum Man9GlcNAc2 1,2-α-mannosidase (23 July 2019)
EC 3.2.1.210 endoplasmic reticulum Man8GlcNAc2 1,2-α-mannosidase (4 October 2019)
EC 3.4.13.23 cysteinylglycine-S-conjugate dipeptidase (4 October 2019)
*EC 3.4.19.13 glutathione γ-glutamate hydrolase (27 February 2019)
*EC 3.5.1.60 N-(long-chain-acyl)ethanolamine deacylase (4 October 2019)
*EC 3.5.1.84 biuret amidohydrolase (27 February 2019)
EC 3.5.1.130 [lysine-biosynthesis-protein LysW]-lysine/ornithine hydrolase (27 February 2019)
EC 3.5.1.131 1-carboxybiuret hydrolase (27 February 2019)
EC 3.5.1.132 [amino group carrier protein]-ornithine hydrolase (5 March 2019)
EC 3.5.1.133 Nα-acyl-L-glutamine aminoacylase (23 July 2019)
EC 3.5.1.134 (indol-3-yl)acetyl-L-aspartate hydrolase (4 October 2019)
*EC 3.5.2.15 cyanuric acid amidohydrolase (27 February 2019)
EC 3.6.1.69 8-oxo-(d)GTP phosphatase (5 December 2019)
EC 3.6.1.70 guanosine-5'-diphospho-5'-[DNA] diphosphatase (5 December 2019)
EC 3.6.1.71 adenosine-5'-diphospho-5'-[DNA] diphosphatase (5 December 2019)
EC 3.6.1.72 DNA-3'-diphospho-5'-guanosine diphosphatase (5 December 2019)
EC 3.6.3.3 transferred now EC 7.2.2.21 (4 October 2019)
EC 3.6.3.16 transferred now EC 7.3.2.7 (20 May 2019)
EC 3.6.3.17 transferred now various members of sub-subclass EC 7.5.2 (20 May 2019)
EC 3.7.1.24 2,4-diacetylphloroglucinol hydrolase (20 May 2019)
EC 3.7.1.25 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase (20 May 2019)
EC 4.1.1.70 transferred now EC 7.2.4.5 (27 February 2019)
EC 4.1.1.115 indoleacetate decarboxylase (27 February 2019)
EC 4.1.1.116 D-ornithine/D-lysine decarboxylase (27 February 2019)
EC 4.1.1.117 2-[(L-alanin-3-ylcarbamoyl)methyl]-2-hydroxybutanedioate decarboxylase (27 February 2019)
EC 4.1.1.118 isophthalyl-CoA decarboxylase (4 October 2019)
EC 4.1.1.119 phenylacetate decarboxylase (5 December 2019)
*EC 4.2.1.139 pterocarpan synthase (27 February 2019)
EC 4.2.1.175 (R)-3-(aryl)lactoyl-CoA dehydratase (4 October 2019)
EC 4.2.3.201 hydropyrene synthase (20 May 2019)
EC 4.2.3.202 hydropyrenol synthase (20 May 2019)
EC 4.2.3.203 isoelisabethatriene synthase (20 May 2019)
EC 4.2.3.204 valerianol synthase (23 July 2019)
EC 4.2.3.205 sodorifen synthase (4 October 2019)
EC 4.2.99.24 thebaine synthase (27 February 2019)
*EC 4.3.2.5 peptidylamidoglycolate lyase (5 December 2019)
EC 4.6.1.23 ribotoxin (4 October 2019)
EC 5.1.1.24 histidine racemase (27 February 2019)
EC 5.1.3.43 sulfoquinovose mutarotase (27 February 2019)
EC 5.4.99.67 4-amino-4-deoxychorismate mutase (4 October 2019)
EC 5.5.1.34 (+)-cis,trans-nepetalactol synthase (5 December 2019)
EC 5.5.1.35 (+)-cis,cis-nepetalactol synthase (5 December 2019)
EC 5.6.1.9 (R)-2-hydroxyacyl-CoA dehydratase activating ATPase (4 October 2019)
*EC 6.2.1.40 4-hydroxybutyrate—CoA ligase (AMP-forming) (27 February 2019)
EC 6.2.1.56 4-hydroxybutyrate—CoA ligase (ADP-forming) (27 February 2019)
EC 6.2.1.57 long-chain fatty acid adenylase/transferase FadD23 (20 May 2019)
EC 6.2.1.58 isophthalate—CoA ligase (4 October 2019)
EC 6.2.1.59 long-chain fatty acid adenylase/transferase FadD26 (4 October 2019)
EC 6.2.1.60 marinolic acid—CoA ligase (4 October 2019)
EC 6.2.1.61 salicylate—[aryl-carrier protein] ligase (5 December 2019)
*EC 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase (20 May 2019)
*EC 6.3.2.43 [amino group carrier protein]—L-2-aminoadipate ligase (5 December 2019)
*EC 6.3.2.39 aerobactin synthase (27 February 2019)
*EC 6.3.2.52 jasmonoyl—L-amino acid ligase (5 December 2019)
EC 6.3.2.54 L-2,3-diaminopropanoate—citrate ligase (27 February 2019)
EC 6.3.2.55 2-[(L-alanin-3-ylcarbamoyl)methyl]-3-(2-aminoethylcarbamoyl)-2-hydroxypropanoate synthase (27 February 2019)
EC 6.3.2.56 staphyloferrin B synthase (27 February 2019)
EC 6.3.2.57 staphyloferrin A synthase (20 May 2019)
EC 6.3.2.58 D-ornithine—citrate ligase (23 July 2019)
*EC 6.3.5.6 asparaginyl-tRNA synthase (glutamine-hydrolysing) (27 February 2019)
*EC 6.3.5.7 glutaminyl-tRNA synthase (glutamine-hydrolysing) (27 February 2019)
EC 6.3.5.13 lipid II isoglutaminyl synthase (glutamine-hydrolysing) (27 February 2019)
EC 7.1.1.9 cytochrome-c oxidase (5 December 2019)
EC 7.2.2.20 ABC-type Zn2+ transporter (23 July 2019)
EC 7.2.2.21 Cd2+-exporting ATPase (4 October 2019)
EC 7.2.4.5 glutaconyl-CoA decarboxylase (27 February 2019)
EC 7.3.2.7 arsenite-transporting ATPase (20 May 2019)
*EC 7.4.2.5 bacterial ABC-type protein transporter (4 October 2019)
EC 7.4.2.10 ABC-type glutathione transporter (20 May 2019)
EC 7.4.2.11 ABC-type methionine transporter (20 May 2019)
EC 7.4.2.12 ABC-type cystine transporter (20 May 2019)
EC 7.4.2.13 ABC-type tyrosine transporter (5 December 2019)
EC 7.5.2.7 ABC-type D-ribose transporter (20 May 2019)
EC 7.5.2.8 ABC-type D-allose transporter (20 May 2019)
EC 7.5.2.9 ABC-type D-galactofuranose transporter (20 May 2019)
EC 7.5.2.10 ABC-type D-xylose transporter (20 May 2019)
EC 7.5.2.11 ABC-type D-galactose transporter (20 May 2019)
EC 7.5.2.12 ABC-type L-arabinose transporter (20 May 2019)
EC 7.5.2.13 ABC-type D-xylose/L-arabinose transporter (20 May 2019)
EC 7.6.2.13 ABC-type autoinducer-2 transporter (20 May 2019)
EC 7.6.2.14 ABC-type aliphatic sulfonate transporter (23 July 2019)
EC 7.6.2.15 ABC-type thiamine transporter (23 July 2019)
EC 7.6.2.16 ABC-type putrescine transporter (23 July 2019)