Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB)

Enzyme Nomenclature

Supplement 25 (2020)

The following documents with additions and amendments to Enzyme Nomenclature have been approved after public review:

New enzymes (17 February 2020, approved 16 March 2020)
New enzymes (6 June 2020, approved 29 June 2020)
New enzymes (11 August 2020, approved 7 September 2020)
New enzymes (24 November 2020, approved 21 December 2020)
The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.

Contents

EC 1.1.1.422 pseudoephedrine dehydrogenase (17 February 2020)
EC 1.1.1.423 ephedrine dehydrogenase (17 February 2020)
*EC 1.1.1.179 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (11 August 2020)
*EC 1.1.1.423 (1R,2S)-ephedrine 1-dehydrogenase (11 August 2020)
EC 1.1.1.424 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming) (11 August 2020)
EC 1.1.7 With an iron-sulfur protein as acceptor (6 June 2020)
EC 1.1.7.1 4-hydroxybenzoyl-CoA reductase (6 June 2020)
EC 1.1.98.7 serine-type anaerobic sulfatase-maturating enzyme (17 February 2020)
*EC 1.2.1.25 branched-chain α-keto acid dehydrogenase system (24 November 2020)
EC 1.2.1.104 pyruvate dehydrogenase system (24 November 2020)
EC 1.2.1.105 2-oxoglutarate dehydrogenase system (24 November 2020)
EC 1.2.2.4 deleted now included in EC 1.2.5.3 (11 August 2020)
*EC 1.3.1.34 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing] (6 June 2020)
EC 1.3.1.124 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (6 June 2020)
EC 1.3.3.16 oxazoline dehydrogenase (11 August 2020)
*EC 1.3.5.3 protoporphyrinogen IX dehydrogenase (quinone) (11 August 2020)
EC 1.3.7.9 transferred now EC 1.1.7.1 (6 June 2020)
*EC 1.3.8.5 short-chain 2-methylacyl-CoA dehydrogenase (24 November 2020)
*EC 1.3.8.11 cyclohexane-1-carbonyl-CoA dehydrogenase (electron-transfer flavoprotein) (17 February 2020)
EC 1.3.8.16 2-amino-4-deoxychorismate dehydrogenase (24 November 2020)
EC 1.13.11.91 3-mercaptopropionate dioxygenase (24 November 2020)
EC 1.3.99.12 transferred now included withEC 1.3.8.5 (24 November 2020)
EC 1.3.99.24 transferred now EC 1.3.8.16 (24 November 2020)
EC 1.4.1.27 glycine cleavage system (24 November 2020)
EC 1.4.3.26 pre-mycofactocin synthase (24 November 2020)
EC 1.6.99.3 deleted now EC 7.1.1.2 (6 June 2020)
EC 1.8.2.7 thiocyanate desulfurase (6 June 2020)
EC 1.8.98.7 cysteine-type anaerobic sulfatase-maturating enzyme (17 February 2020)
EC 1.11.1.15 transferred now described by EC 1.11.1.24, EC 1.11.1.25, EC 1.11.1.26, EC 1.11.1.27, EC 1.11.1.28, and EC 1.11.1.29 (17 February 2020)
EC 1.11.1.24 thioredoxin-dependent peroxiredoxin (17 February 2020)
EC 1.11.1.25 glutaredoxin-dependent peroxiredoxin (17 February 2020)
EC 1.11.1.26 NADH-dependent peroxiredoxin (17 February 2020)
EC 1.11.1.27 glutathione-dependent peroxiredoxin (17 February 2020)
EC 1.11.1.28 lipoyl-dependent peroxiredoxin (17 February 2020)
EC 1.11.1.29 mycoredoxin-dependent peroxiredoxin (17 February 2020)
EC 1.11.2.6 L-tyrosine peroxygenase (6 June 2020)
EC 1.13.11.90 [1-hydroxy-2-(trimethylamino)ethyl]phosphonate dioxygenase (glycine-betaine-forming) (6 June 2020)
EC 1.14.11.72 [2-(trimethylamino)ethyl]phosphonate dioxygenase (6 June 2020)
EC 1.14.11.76 L-glutamate 3(R)-hydroxylase (24 November 2020)
EC 1.14.11.73 [protein]-arginine 3-hydroxylase (11 August 2020)
EC 1.14.11.74 L-isoleucine 31-dioxygenase (11 August 2020)
EC 1.14.11.75 31-hydroxy-L-isoleucine 4-dioxygenase (11 August 2020)
EC 1.14.13.116 transferred now EC 1.14.14.174 (11 August 2020)
EC 1.14.13.190 transferred now EC 1.14.14.175 (11 August 2020)
*EC 1.14.14.139 5β-cholestane-3α,7α-diol 12α-hydroxylase (24 November 2020)
EC 1.14.14.172 3,5,6-trichloropyridin-2-ol monooxygenase (6 June 2020)
EC 1.14.14.173 2,4,6-trichlorophenol monooxygenase (6 June 2020)
EC 1.14.14.174 geranylhydroquinone 3''-hydroxylase (11 August 2020)
EC 1.14.14.175 ferruginol synthase (11 August 2020)
EC 1.14.14.176 taxadiene 5α-hydroxylase (11 August 2020)
EC 1.14.15.38 N,N-dimethyl phenylurea N-demethylase (24 November 2020)
EC 1.14.16.3 deleted (6 June 2020)
*EC 1.14.16.5 alkylglycerol monooxygenase (17 February 2020)
*EC 1.14.16.6 mandelate 4-monooxygenase (17 February 2020)
*EC 1.14.17.1 dopamine β-monooxygenase (17 February 2020)
EC 1.14.18.8 transferred now included with EC 1.14.14.139 (24 November 2020)
EC 1.14.18.12 2-hydroxy fatty acid dioxygenase (17 February 2020)
EC 1.14.19.77 plasmanylethanolamine desaturase (6 June 2020)
EC 1.14.99.19 transferred now EC 1.14.19.77 (6 June 2020)
EC 1.14.99.37 transferred now EC 1.14.14.176 (11 August 2020)
*EC 1.14.99.38 cholesterol 25-monooxygenase (24 November 2020)
EC 1.14.99.67 α-N-dichloroacetyl-p-aminophenylserinol N-oxygenase (24 November 2020)
EC 1.14.99.68 4-aminobenzoate N-oxygenase (24 November 2020)
EC 1.14.99.69 tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase (24 November 2020)
EC 1.16.1.3 deleted (6 June 2020)
EC 1.16.1.5 deleted (6 June 2020)
*EC 1.16.1.8 [methionine synthase] reductase (17 February 2020)
*EC 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase (17 February 2020)
EC 1.17.9.2 (+)-pinoresinol hydroxylase (11 August 2020)
EC 1.17.98.4 formate dehydrogenase (hydrogenase) (24 November 2020)
EC 1.17.99.7 transferred now EC 1.17.98.4
EC 1.17.99.8 limonene dehydrogenase (17 February 2020)
EC 1.17.99.9 heme a synthase (24 November 2020)
EC 1.17.99.10 steroid C-25 hydroxylase (24 November 2020)
EC 1.17.99.11 3-oxo-Δ1-steroid hydratase/dehydrogenase (24 November 2020)
*EC 1.20.4.1 arsenate reductase (glutathione/glutaredoxin) (17 February 2020)
*EC 2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase (6 June 2020)
*EC 2.1.1.355 [histone H3]-lysine9 N-trimethyltransferase (11 August 2020)
*EC 2.1.1.356 [histone H3]-lysine27 N-trimethyltransferase (11 August 2020)
EC 2.1.1.358 deleted, now covered by EC 2.1.1.359 (11 August 2020)
EC 2.1.1.364 [histone H3]-lysine4 N-methyltransferase (6 June 2020)
EC 2.1.1.365 MMP 1-O-methyltransferase (6 June 2020)
EC 2.1.1.366 [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase (11 August 2020)
EC 2.1.1.367 [histone H3]-lysine9 N-methyltransferase (11 August 2020)
EC 2.1.1.368 [histone H3]-lysine9 N-dimethyltransferase (11 August 2020)
EC 2.1.1.369 [histone H3]-lysine27 N-methyltransferase (11 August 2020)
EC 2.1.1.370 [histone H3]-lysine4 N-dimethyltransferase (11 August 2020)
EC 2.1.1.371 [histone H3]-lysine27 N-dimethyltransferase (11 August 2020)
EC 2.1.1.372 [histone H4]-lysine20 N-trimethyltransferase (11 August 2020)
EC 2.1.1.373 2-hydroxy-4-(methylsulfanyl)butanoate S-methyltransferase (24 November 2020)
EC 2.1.1.374 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase (24 November 2020)
EC 2.2.1.13 apulose-4-phosphate transketolase (24 November 2020)
*EC 2.3.1.179 β-ketoacyl-[acyl-carrier-protein] synthase II (24 November 2020)
*EC 2.3.1.190 acetoin dehydrogenase system (24 November 2020)
EC 2.3.2.34 E2 NEDD8-conjugating enzyme (6 June 2020)
EC 2.3.2.35 capsaicin synthase (6 June 2020)
EC 2.3.2.36 RING-type E3 ubiquitin transferase (cysteine targeting) (24 November 2020)
EC 2.4.1.375 rhamnogalacturonan I galactosyltransferase (6 June 2020)
EC 2.4.1.376 EGF-domain serine glucosyltransferase (6 June 2020)
*EC 2.4.2.29 tRNA-guanosine34 preQ1 transglycosylase (24 November 2020)
*EC 2.4.2.42 UDP-D-xylose:β-D-glucoside α-1,3-D-xylosyltransferase (17 February 2020)
EC 2.4.2.62 xylosyl α-1,3-xylosyltransferase (6 June 2020)
EC 2.4.2.63 EGF-domain serine xylosyltransferase (6 June 2020)
EC 2.4.2.64 tRNA-guanosine34 queuine transglycosylase (24 November 2020)
EC 2.4.99.22 N-acetylglucosaminide α-(2,6)-sialyltransferase (6 June 2020)
*EC 2.5.1.25 tRNA-uridine aminocarboxypropyltransferase (24 November 2020)
EC 2.5.1.153 adenosine tuberculosinyltransferase (24 November 2020)
*EC 2.6.1.23 4-hydroxyglutamate transaminase (6 June 2020)
EC 2.6.1.119 vanillin aminotransferase (6 June 2020)
*EC 2.7.1.8 glucosamine kinase (17 February 2020)
*EC 2.7.1.48 uridine/cytidine kinase (6 June 2020)
*EC 2.7.1.147 ADP-specific glucose/glucosamine kinase (17 February 2020)
EC 2.7.1.231 3-oxoisoapionate kinase (6 June 2020)
EC 2.7.2.13 deleted (6 June 2020)
EC 2.7.2.17 [amino group carrier protein]-L-2-aminoadipate 6-kinase (17 February 2020)
EC 2.7.4.33 AMP-polyphosphate phosphotransferase (6 June 2020)
*EC 2.7.7.2 FAD synthase (17 February 2020)
*EC 2.7.7.68 2-phospho-L-lactate guanylyltransferase (11 August 2020)
*EC 2.7.7.69 GDP-L-galactose/GDP-D-glucose: hexose 1-phosphate guanylyltransferase (24 November 2020)
*EC 2.7.7.88 GDP polyribonucleotidyltransferase (24 November 2020)
EC 2.7.7.104 2-hydroxyethylphosphonate cytidylyltransferase (6 June 2020)
EC 2.7.7.105 phosphoenolpyruvate guanylyltransferase (11 August 2020)
EC 2.7.7.106 3-phospho-D-glycerate guanylyltransferase (11 August 2020)
*EC 2.7.8.28 2-phospho-L-lactate transferase (11 August 2020)
EC 2.8.3.26 succinyl-CoA:mesaconate CoA transferase (17 February 2020)
EC 2.9.1.3 tRNA 2-selenouridine synthase (17 February 2020)
EC 3.1.1.115 D-apionolactonase (24 November 2020)
EC 3.1.3.31 deleted (24 November 2020)
EC 3.1.3.108 nocturnin (17 February 2020)
EC 3.1.7.8 transferred now part of EC 2.5.1.153 (24 November 2020)
EC 3.1.7.9 transferred now part of EC 2.5.1.153 (24 November 2020)
EC 3.1.27.3 transferred now EC 4.6.1.24 (17 February 2020)
EC 3.2.1.44 transferred now EC 3.2.1.211 and EC 3.2.1.212 (17 February 2020)
*EC 3.2.1.155 xyloglucan-specific endo-processive β-1,4-glucanase (17 February 2020)
EC 3.2.1.211 endo-(1→3)-fucoidanase (17 February 2020)
EC 3.2.1.212 endo-(1→4)-fucoidanase (17 February 2020)
EC 3.2.1.213 galactan exo-1,6-β-galactobiohydrolase (non-reducing end) (17 February 2020)
EC 3.2.1.214 exo β-1,2-glucooligosaccharide sophorohydrolase (non-reducing end) (6 June 2020)
*EC 3.2.2.9 adenosylhomocysteine nucleosidase (6 June 2020)
EC 3.4.17.24 tubulin-glutamate carboxypeptidase (17 February 2020)
*EC 3.5.1.110 ureidoacrylate amidohydrolase (6 June 2020)
EC 3.5.1.135 N4-acetylcytidine amidohydrolase (6 June 2020)
EC 3.5.1.136 N,N′-diacetylchitobiose non-reducing end deacetylase (24 November 2020)
EC 3.6.1.3 deleted (6 June 2020)
EC 3.6.3.11 deleted (6 June 2020)
EC 3.6.1.73 inosine/xanthosine triphosphatase (17 February 2020)
EC 3.7.1.26 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase (17 February 2020)
EC 3.7.1.27 neryl diphosphate diphosphatase (24 November 2020)
EC 3.8.1.1 deleted (6 June 2020)
EC 3.13.1.9 S-inosyl-L-homocysteine hydrolase (17 February 2020)
EC 4.1.1.120 3-oxoisoapionate decarboxylase (6 June 2020)
EC 4.1.1.121 3-oxoisoapionate-4-phosphate decarboxylase (6 June 2020)
EC 4.1.2.41 transferred now EC 4.1.2.61 (17 February 2020)
EC 4.1.2.61 feruloyl-CoA hydratase/lyase (17 February 2020)
EC 4.1.2.62 5-deoxyribulose 1-phosphate aldolase (6 June 2020)
*EC 4.2.1.96 4a-hydroxytetrahydrobiopterin dehydratase (17 February 2020)
EC 4.2.1.101 transferred now EC 4.1.2.61 (17 February 2020)
EC 4.2.2.27 pectin monosaccharide-lyase (17 February 2020)
*EC 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase (17 February 2020)
EC 4.6.1.24 ribonuclease T1 (17 February 2020)
EC 4.6.1.25 bacteriophage T4 restriction endoribonuclease RegB (17 February 2020)
*EC 4.99.1.3 sirohydrochlorin cobaltochelatase (6 June 2020)
EC 5.1.3.12 deleted (11 August 2020)
*EC 5.1.3.18 GDP-mannose 3,5-epimerase (6 June 2020)
EC 5.1.3.44 mannose 2-epimerase (24 November 2020)
EC 5.3.1.36 D-apiose isomerase (24 November 2020)
EC 6.2.1.62 3,4-dihydroxybenzoate—[aryl-carrier protein] ligase (17 February 2020)
EC 6.2.1.63 L-arginine—[L-arginyl-carrier protein] ligase (17 February 2020)
EC 6.2.1.65 salicylate—CoA ligase (11 August 2020)
EC 6.2.2 Amide-thiol ligases (6 June 2020)
EC 6.2.2.1 thioglycine synthase (6 June 2020)
EC 6.2.2.2 oxazoline synthase (11 August 2020)
EC 6.2.2.3 thiazoline synthase (11 August 2020)
EC 6.5.1.9 cyclic 2,3-diphosphoglycerate synthase (6 June 2020)
*EC 7.1.1.7 quinol oxidase (electrogenic, proton-motive force generating) (17 February 2020)

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