New enzymes (8 April 2021, approved 4 May 2021)The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (21 June 2021, approved 19 July 2021)
New enzymes (19 November 2021, approved 14 December 2021)
*EC 1.1.1.24 quinate/shikimate dehydrogenase (NAD+) (8 April 2021)
*EC 1.1.1.25 shikimate dehydrogenase (NADP+) (8 April 2021)
*EC 1.1.1.282 quinate/shikimate dehydrogenase [NAD(P)+] (8 April 2021)
EC 1.1.1.425 levoglucosan dehydrogenase (8 April 2021)
EC 1.1.1.426 UDP-N-acetyl-α-D-quinovosamine dehydrogenase (21 June 2021)
*EC 1.1.5.8 quinate/shikimate dehydrogenase (quinone) (8 April 2021)
EC 1.1.5.14 fructose 5-dehydrogenase (21 June 2021)
EC 1.1.99.11 transferred now EC 1.1.5.14 (21 June 2021)
*EC 1.2.1.20 glutarate-semialdehyde dehydrogenase (21 June 2021)
EC 1.2.1.106 [amino-group carrier protein]-5-phospho-L-glutamate reductase (8 April 2021)
EC 1.2.1.107 glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) (21 June 2021)
*EC 1.3.1.109 butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin) (8 April 2021)
EC 1.3.8.17 dehydro coenzyme F420 reductase (8 April 2021)
EC 1.3.98.7 [mycofactocin precursor peptide]-tyrosine decarboxylase (8 April 2021)
*EC 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H] (8 April 2021)
EC 1.5.1.53 methylenetetrahydrofolate reductase (NADPH) (8 April 2021)
EC 1.5.1.54 methylenetetrahydrofolate reductase (NADH) (8 April 2021)
*EC 1.5.7.1 methylenetetrahydrofolate reductase (ferredoxin) (8 April 2021)
*EC 1.7.2.6 hydroxylamine dehydrogenase (19 November 2021)
*EC 1.7.2.7 hydrazine synthase (19 November 2021)
EC 1.7.2.9 hydroxylamine oxidase (19 November 2021)
EC 1.10.2.1 deleted, now covered byEC 7.2.1.3 (8 April 2021)
EC 1.13.11.92 fatty acid α-dioxygenase (21 June 2021)
EC 1.14.11.77 alkyl sulfatase (21 June 2021)
EC 1.14.13.106 transferred, now EC 1.14.15.39 (8 April 2021)
EC 1.14.13.248 L-aspartate N-monooxygenase (nitrosuccinate-forming) (19 November 2021)
EC 1.14.13.249 3-amino-4-hydroxybenzoate 2-monooxygenase (19 November 2021)
EC 1.14.13.250 nitrosourea synthase (19 November 2021)
EC 1.14.14.177 ultra-long-chain fatty acid ω-hydroxylase (8 April 2021)
EC 1.14.15.39 epi-isozizaene 5-monooxygenase (8 April 2021)
EC 1.14.19.78 decanoyl-[acyl-carrier protein] acetylenase (8 April 2021)
EC 1.16.1.4 deleted (19 November 2021)
*EC 1.16.1.6 cyanocobalamin reductase (21 June 2021)
EC 1.16.3.4 cuproxidase (19 November 2021)
EC 1.16.99 With unknown physiological acceptors (21 June 2021)
EC 1.16.99.1 [Co(II) methylated amine-specific corrinoid protein] reductase (21 June 2021)
*EC 2.1.1.57 methyltransferase cap1 (21 June 2021)
*EC 2.1.1.61 tRNA 5-(aminomethyl)-2-thiouridylate-methyltransferase (21 June 2021)
*EC 2.1.1.137 arsenite methyltransferase (19 November 2021)
*EC 2.1.1.296 methyltransferase cap2 (21 June 2021)
EC 2.1.1.375 NNS virus cap methyltransferase (8 April 2021)
EC 2.1.1.376 glycine betaine—corrinoid protein Co-methyltransferase (21 June 2021)
EC 2.1.1.377 [methyl-Co(III) glycine betaine-specific corrinoid protein]—coenzyme M methyltransferase (21 June 2021)
EC 2.1.1.378 [methyl-Co(III) glycine betaine-specific corrinoid protein]—tetrahydrofolate methyltransferase (21 June 2021)
EC 2.1.1.379 [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase (21 June 2021)
EC 2.1.1.380 3-amino-4-hydroxybenzoate 4-O-methyltransferase (19 November 2021)
EC 2.1.1.381 arginine Nω-methyltransferase (19 November 2021)
EC 2.1.1.383 L-carnitine—corrinoid protein Co-methyltransferase (19 November 2021)
EC 2.1.3.16 ureidoglycine carbamoyltransferase (19 November 2021)
*EC 2.1.2.2 phosphoribosylglycinamide formyltransferase 1 (8 April 2021)
EC 2.1.2.14 GDP-perosamine N-formyltransferase (21 June 2021)
EC 2.2.1.14 6-deoxy-6-sulfo-D-fructose transaldolase (8 April 2021)
*EC 2.3.1.108 α-tubulin N-acetyltransferase (19 November 2021)
*EC 2.3.1.129 acyl-[acyl-carrier-protein]—UDP-N-acetylglucosamine O-acyltransferase (19 November 2021)
*EC 2.3.1.180 β-ketoacyl-[acyl-carrier-protein] synthase III (8 April 2021)
EC 2.3.1.182 transferred now EC 2.3.3.21 (19 November 2021)
*EC 2.3.1.191 UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase (21 June 2021)
*EC 2.3.1.241 Kdo2-lipid IVA acyltransferase (19 November 2021)
*EC 2.3.1.243 acyl-Kdo2-lipid IVA acyltransferase (19 November 2021)
*EC 2.3.1.245 3-hydroxy-5-phosphooxypentane-2,4-dione thiolase (8 April 2021)
EC 2.3.1.300 branched-chain β-ketoacyl-[acyl-carrier-protein] synthase (8 April 2021)
EC 2.3.1.301 mycobacterial β-ketoacyl-[acyl carrier protein] synthase III (8 April 2021)
EC 2.3.1.302 hydroxycinnamoyl-CoA:5-hydroxyanthranilate N-hydroxycinnamoyltransferase (8 April 2021)
EC 2.3.1.303 α-L-Rha-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Gal-PP-Und 2IV-O-acetyltransferase (8 April 2021)
EC 2.3.1.304 poly[(R)-3-hydroxyalkanoate] polymerase (21 June 2021)
EC 2.3.1.305 acyl-[acyl-carrier protein]—UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucopyranose N-acyltransferase (19 November 2021)
EC 2.3.1.306 acetyl-CoA:lysine N6-acetyltransferase (19 November 2021)
EC 2.3.1.307 6-diazo-5-oxo-L-norleucine Nα-acetyltranferase (19 November 2021)
EC 2.3.3.21 (R)-citramalate synthase (19 November 2021)
*EC 2.4.1.60 CDP-abequose:α-D-Man-(1→4)-α-L-Rha-(1→3)-α-D-Gal-PP-Und α-1,3-abequosyltransferase (8 April 2021)
*EC 2.4.1.182 lipid-A-disaccharide synthase (21 June 2021)
EC 2.4.1.377 dTDP-Rha:α-D-Gal-diphosphoundecaprenol α-1,3-rhamnosyltransferase (8 April 2021)
EC 2.4.1.378 GDP-mannose:α-L-Rha-(1→3)-α-D-Gal-PP-Und α-1,4-mannosyltransferase (8 April 2021)
EC 2.4.1.379 GDP-Man:α-D-Gal-diphosphoundecaprenol α-1,3-mannosyltransferase (8 April 2021)
EC 2.4.1.380 GDP-Man:α-D-Man-(1→3)-α-D-Gal diphosphoundecaprenol α-1,2-mannosyltransferase (8 April 2021)
EC 2.4.1.381 dTDP-Rha:α-D-Man-(1→3)-α-D-Gal diphosphoundecaprenol α-1,2-rahmnosyltransferase (8 April 2021)
EC 2.4.1.382 CDP-abequose:α-L-Rha2OAc-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-α-D-Gal-PP-Und α-1,3-abequosyltransferase (8 April 2021)
EC 2.4.1.383 GDP-Man:α-L-Rha-(1→3)-α-D-Gal-PP-Und β-1,4-mannosyltransferase (8 April 2021)
EC 2.4.1.384 NDP-glycosyltransferase (21 June 2021)
EC 2.4.1.385 sterol 27-β-glucosyltransferase (19 November 2021)
EC 2.4.1.386 GlcNAc-β-1,3-Gal β-1,6-N-acetylglucosaminyltransferase (distally acting) (19 November 2021)
*EC 2.4.2.2 pyrimidine-nucleoside phosphorylase (21 June 2021)
*EC 2.4.99.13 (Kdo)-lipid IVA 3-deoxy-D-manno-octulosonic acid transferase (19 November 2021)
*EC 2.5.1.151 alkylcobalamin dealkylase (19 November 2021)
EC 2.5.1.154 corrinoid adenosyltransferase EutT (19 November 2021)
*EC 2.6.1.19 4-aminobutyrate—2-oxoglutarate transaminase (19 November 2021)
*EC 2.6.1.82 putrescine—2-oxoglutarate transaminase (21 June 2021)
EC 2.6.1.120 β-alanine—2-oxoglutarate transaminase (19 November 2021)
EC 2.6.1.121 8-amino-7-oxononanoate carboxylating dehydrogenase (19 November 2021)
EC 2.6.1.122 UDP-N-acetyl-3-dehydro-α-D-glucosamine 3-aminotranferase (19 November 2021)
EC 2.6.1.123 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming) (19 November 2021)
*EC 2.7.1.11 6-phosphofructokinase (21 June 2021)
*EC 2.7.1.130 tetraacyldisaccharide 4′-kinase (19 November 2021)
EC 2.7.1.232 levoglucosan kinase (8 April 2021)
EC 2.7.1.233 apulose kinase (21 June 2021)
EC 2.7.1.234 D-tagatose-1-phosphate kinase (19 November 2021)
EC 2.7.1.235 lipopolysaccharide core heptose(I) kinase (19 November 2021)
EC 2.7.2.18 fatty acid kinase (21 June 2021)
*EC 2.7.4.1 ATP-polyphosphate phosphotransferase (8 April 2021)
EC 2.7.4.34 GDP-polyphosphate phosphotransferase (8 April 2021)
*EC 2.7.7.50 mRNA guanylyltransferase (8 April 2021)
EC 2.7.7.58 transferred now EC 6.2.1.71 (21 June 2021)
EC 2.7.7.107 (2-aminoethyl)phosphonate cytidylyltransferase (19 November 2021)
EC 2.7.10.3 bacterial tyrosine kinase (19 November 2021)
EC 2.8.2.40 ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (21 June 2021)
EC 2.8.4.6 S-methyl-1-thioxylulose 5-phosphate methylthiotransferase (19 November 2021)
EC 3.1.1.116 sn-1-specific diacylglycerol lipase (8 April 2021)
EC 3.1.1.117 (4-O-methyl)-D-glucuronate—lignin esterase (8 April 2021)
EC 3.1.1.118 phospholipid sn-1 acylhydrolase (21 June 2021)
EC 3.1.4.61 cyclic 2,3-diphosphoglycerate hydrolase (8 April 2021)
*EC 3.1.6.1 arylsulfatase (type I) (21 June 2021)
*EC 3.1.6.19 (R)-specific secondary-alkylsulfatase (type III) (21 June 2021)
EC 3.1.6.21 linear primary-alkylsulfatase (21 June 2021)
EC 3.1.6.22 branched primary-alkylsulfatase (21 June 2021)
EC 3.1.7.13 neryl diphosphate diphosphatase (19 November 2021)
EC 3.1.21.10 crossover junction endodeoxyribonuclease (21 June 2021)
EC 3.1.22.4 transferred entry now EC 3.1.21.10 (19 July 2021) (21 June 2021)
EC 3.2.1.47 deleted covered by EC 3.2.1.22 (21 June 2021)
EC 3.2.1.66 deleted, covered by EC 3.2.1.40 (19 November 2021)
EC 3.2.1.134 transferred, now EC 4.2.1.179 (19 November 2021)
EC 3.2.1.215 arabinogalactan exo α-(1,3)-α-D-galactosyl-(1→3)-L-arabinofuranosidase (non-reducing end) (19 November 2021)
EC 3.4.14.14 [mycofactocin precursor peptide] peptidase (21 June 2021)
EC 3.4.17.25 glutathione-S-conjugate glycine hydrolase (19 November 2021)
*EC 3.5.1.108 UDP-3-O-acyl-N-acetylglucosamine deacetylase (19 November 2021)
EC 3.5.1.137 N-methylcarbamate hydrolase (19 November 2021)
*EC 3.6.1.54 UDP-2,3-diacylglucosamine diphosphatase (19 November 2021)
EC 3.6.1.74 mRNA 5′-phosphatase (8 April 2021)
EC 3.6.4.12 transferred, now EC 5.6.2.3 and EC 5.6.2.4 (19 November 2021)
EC 3.7.1.27 transferred, now EC 3.1.7.13 (19 November 2021)
EC 3.7.1.28 3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase (21 June 2021)
EC 4.1.2.63 2-hydroxyacyl-CoA lyase (21 June 2021)
*EC 4.1.3.3 N-acetylneuraminate lyase (21 June 2021)
EC 4.1.99.26 3-amino-5-[(4-hydroxyphenyl)methyl]-4,4-dimethylpyrrolidin-2-one synthase (8 April 2021)
EC 4.2.1.176 L-lyxonate dehydratase (21 June 2021)
EC 4.2.1.177 (2S)-3-sulfopropanediol dehydratase (21 June 2021)
EC 4.2.1.178 difructose-dianhydride-III synthase (19 November 2021)
EC 4.2.1.179 difructose-anhydride-I synthase (19 November 2021)
EC 4.3.99.5 nitrosuccinate lyase (19 November 2021)
*EC 4.4.1.14 1-aminocyclopropane-1-carboxylate synthase (8 April 2021)
EC 4.4.1.38 isethionate sulfite-lyase (21 June 2021)
EC 4.4.1.39 C-phycoerythrin α-cysteine-82 phycoerythrobilin lyase (21 June 2021)
EC 4.4.1.40 C-phycoerythrin β-cysteine-48/59 phycoerythrobilin lyase (21 June 2021)
EC 4.4.1.41 (2S)-3-sulfopropanediol sulfolyase (21 June 2021)
EC 4.8 Nitrogen-oxygen lyases (19 November 2021)
EC 4.8.1 Hydro-lyases (19 November 2021)
EC 4.8.1.1 L-piperazate synthase (19 November 2021)
EC 4.8.1.2 aliphatic aldoxime dehydratase (19 November 2021)
EC 4.8.1.3 indoleacetaldoxime dehydratase (19 November 2021)
EC 4.8.1.4 phenylacetaldoxime dehydratase (19 November 2021)
EC 4.98 ATP-independent chelatases (19 November 2021)
EC 4.98.1 Forming coordination complexes (19 November 2021)
EC 4.98.1.1 protoporphyrin ferrochelatase (19 November 2021)
EC 4.99.1.1 ransferred, now EC 4.98.1.1 (19 November 2021)
EC 4.99.1.5 transferred. now EC 4.8.1.2 (19 November 2021)
EC 4.99.1.6 transferred. now EC 4.8.1.3 (19 November 2021)
EC 4.99.1.7 transferred. now EC 4.8.1.4 (19 November 2021)
*EC 5.1.3.24 N-acetylneuraminate epimerase (21 June 2021)
*EC 5.3.1.9 glucose-6-phosphate isomerase (19 November 2021)
EC 5.3.99.12 lachrymatory-factor synthase (19 November 2021)
EC 5.3.3.23 S-methyl-5-thioribulose 1-phosphate isomerase (8 April 2021)
EC 5.6.2.3 DNA 5′-3′ helicase (19 November 2021)
EC 5.6.2.4 DNA 3′-5′ helicase (19 November 2021)
EC 6.2.1.66 glyine—[glycyl-carrier protein] ligase (8 April 2021)
EC 6.2.1.67 L-alanine—[L-alanyl-carrier protein] ligase (8 April 2021)
EC 6.2.1.68 L-glutamate—[L-glutamyl-carrier protein] ligase (8 April 2021)
EC 6.2.1.69 L-cysteine—[L-cysteinyl-carrier protein] ligase (21 June 2021)
EC 6.2.1.70 L-threonine—[L-threonyl-carrier protein] ligase (21 June 2021)
EC 6.2.1.71 2,3-dihydroxybenzoate—[aryl-carrier protein] ligase (21 June 2021)
EC 6.2.1.72 L-serine—[L-seryl-carrier protein] ligase (21 June 2021)
EC 6.2.1.73 L-tryptophan—[L-tryptophyl-carrier protein] ligase (21 June 2021)
EC 6.2.1.74 3-amino-5-hydroxybenzoate—[acyl-carrier protein] ligase (21 June 2021)
EC 6.3.1.21 phosphoribosylglycinamide formyltransferase 2 (8 April 2021)
EC 6.3.2.59 3-methyl-D-ornithine—L-lysine ligase (8 April 2021)
EC 6.3.2.60 glutamate—[amino group carrier protein] ligase (8 April 2021)
EC 6.3.2.61 tubulin-glutamate ligase (19 November 2021)
EC 6.3.2.62 β-tubulin-glutamate ligase (19 November 2021)
EC 6.3.4.25 2-amino-2′-deoxyadenylo-succinate synthase (21 June 2021)
EC 6.7 Forming nitrogen-nitrogen bonds (19 November 2021)
EC 6.7.1 Forming diazo bonds (19 November 2021)
EC 6.7.1.1 3-amino-2-hydroxy-4-methoxybenzoate diazotase (19 November 2021)
*EC 7.1.1.9 cytochrome-c oxidase (8 April 2021)
EC 7.1.1.10 ferredoxin—quinone oxidoreductase (H+-translocating) (8 April 2021)
EC 7.1.1.11 ferredoxin—NAD+ oxidoreductase (H+-transporting) (21 June 2021)
EC 7.1.3.2 Na+-exporting diphosphatase (21 June 2021)
EC 7.2.2.22 P-type Mn2+ transporter (8 April 2021)
EC 7.4.2.14 ABC-type antigen peptide transporter (8 April 2021)