New enzymes (8 April 2022, approved 4 May 2022)The entries were added on the date indicated and fully approved after a month. An asterisk before 'EC' indicates that this is an amendment to an existing enzyme rather than a new enzyme entry.
New enzymes (1 June 2022, approved 29 June 2022)
New enzymes (6 July 2022, approved 1 August 2022)
New enzymes (19 December 2022, approved 12 January 2023)
Contents
*EC 1.1.1.104 4-oxoproline reductase (1 June 2022)
*EC 1.1.1.307 D-xylose reductase [NAD(P)H] (1 June 2022)
*EC 1.1.1.313 sulfoacetaldehyde reductase (NADPH) (1 June 2022)
*EC 1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+] (8 April 2022)
EC 1.1.1.427 D-arabinose 1-dehydrogenase (NADP+) (8 April 2022)
EC 1.1.1.428 4-methylthio 2-oxobutanoate reductase (NADH) (8 April 2022)
EC 1.1.1.429 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase (8 April 2022)
EC 1.1.1.430 D-xylose reductase (NADH) (1 June 2022)
EC 1.1.1.431 D-xylose reductase (NADPH) (1 June 2022)
EC 1.1.1.432 6-dehydroglucose reductase (1 June 2022)
EC 1.1.1.433 sulfoacetaldehyde reductase (NADH) (1 June 2022)
EC 1.1.1.434 2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase (12 January 2023)
EC 1.1.1.435 L-fucose dehydrogenase (12 January 2023)
EC 1.1.1.436 lactate dehydrogenase (NAD+,ferredoxin) (12 January 2023)
EC 1.1.1.437 5-dehydrofumagillol 5-reductase (12 January 2023)
EC 1.1.2.11 glucoside 3-dehydrogenase (cytochrome c) (1 June 2022)
*EC 1.1.3.29 N-acylhexosamine oxidase (8 April 2022)
EC 1.1.3.50 C-glycoside oxidase (6 July 2022)
*EC 1.1.99.13 glucoside 3-dehydrogenase (acceptor) (1 June 2022)
EC 1.3.1.110 transferred now EC 1.1.1.436 (12 January 2023)
EC 1.3.1.125 acrylate reductase (12 January 2023)
EC 1.3.2.4 fumarate reductase (cytochrome) (12 January 2023)
EC 1.3.3.17 benzylmalonyl-CoA dehydrogenase (8 April 2022)
*EC 1.3.5.1 succinate dehydrogenase (1 June 2022)
EC 1.3.5.4 transferred (1 June 2022)
EC 1.3.99.41 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase (8 April 2022)
EC 1.4.2.2 nicotine dehydrogenase (12 January 2023)
EC 1.4.2.3 pseudooxynicotine dehydrogenase (12 January 2023)
EC 1.4.3.24 transferred now EC 1.4.2.3 (12 January 2023)
EC 1.4.3.27 homospermidine oxidase (12 January 2023)
*EC 1.4.1.21 aspartate dehydrogenase (1 June 2022)
EC 1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)+] (1 June 2022)
*EC 1.5.3.1 sarcosine oxidase (formaldehyde-forming) (8 April 2022)
EC 1.5.3.24 sarcosine oxidase (5,10-methylenetetrahydrofolate-forming) (8 April 2022)
*EC 1.5.3.10 dimethylglycine oxidase (1 June 2022)
EC 1.5.3.25 fructosyl amine oxidase (glucosone-forming) (1 June 2022)
EC 1.5.3.26 fructosyl amine oxidase (fructosamine-forming) (1 June 2022)
EC 1.5.7.3 N,N-dimethylglycine/sarcosine dehydrogenase (ferredoxin) (1 June 2022)
*EC 1.5.8.3 sarcosine dehydrogenase (8 April 2022)
EC 1.8.1.3 deleted (1 June 2022)
EC 1.13.11.93 2-oxoadipate dioxygenase/decarboxylase (1 June 2022)
EC 1.14.11.78 (R)-3-[(carboxymethyl)amino]fatty acid dioxygenase/decarboxylase (1 June 2022)
EC 1.14.11.79 protein-L-histidine (3S)-3-hydroxylase (1 June 2022)
EC 1.14.11.80 methylcytosine dioxygenase (12 January 2023)
EC 1.14.11.81 (–)-cyclopenine synthase (12 January 2023)
EC 1.14.11.82 5-dehydro-6-demethoxyfumagillol dioxygenase (12 January 2023)
EC 1.14.13.147 transferred (1 June 2022)
*EC 1.14.13.211 rifampicin monooxygenase (12 January 2023)
EC 1.14.13.251 glycine betaine monooxygenase (1 June 2022)
*EC 1.14.14.147 22α-hydroxysteroid 23-monooxygenase (8 April 2022)
EC 1.14.14.178 steroid 22S-hydroxylase (8 April 2022)
EC 1.14.14.179 brassinosteroid 6-oxygenase (1 June 2022)
EC 1.14.14.180 brassinolide synthase (1 June 2022)
EC 1.14.14.181 sulfoquinovose monooxygenase (1 June 2022)
EC 1.14.14.182 taxoid 7β-hydroxylase (1 June 2022)
EC 1.14.14.183 taxoid 2α-hydroxylase (1 June 2022)
*EC 1.14.14.173 2,4,6-trichlorophenol monooxygenase (12 January 2023)
EC 1.14.14.184 5-dehydro-6-demethoxyfumagillol synthase (12 January 2023)
EC 1.14.19.79 3β,22α-dihydroxysteroid 3-dehydrogenase (8 April 2022)
EC 1.14.99.51 transferred (1 June 2022)
EC 1.21.98.5 tetraether lipid synthase (12 January 2023)
EC 2.1.1.382 methoxylated aromatic compound—corrinoid protein Co-methyltransferase (1 June 2022)
EC 2.1.1.384 [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]—tetrahydromethanopterin methyltransferase (1 June 2022)
EC 2.1.1.385 [methyl-Co(III) methoxylated-aromatic-compound-specific corrinoid protein]—tetrahydrofolate methyltransferase (1 June 2022)
EC 2.1.1.386 small RNA 2'-O-methyltransferase (12 January 2023)
EC 2.1.1.387 5-dehydro-6-demethoxy-6-hydroxyfumagillol O-methyltransferase (12 January 2023)
EC 2.2.1.15 6-deoxy-6-sulfo-D-fructose transketolase (1 June 2022)
EC 2.3.1.308 tubulin N-terminal N-acetyltransferase NAT9 (8 April 2022)
EC 2.3.1.309 [β-tubulin]-L-lysine N-acetyltransferase (6 July 2022)
EC 2.3.1.310 benzoylsuccinyl-CoA thiolase (6 July 2022)
EC 2.3.1.311 tRNA carboxymetyluridine synthase (12 January 2023)
EC 2.4.1.387 isomaltosyltransferase (8 April 2022)
EC 2.4.1.388 glucosylgalactose phosphorylase (8 April 2022)
*EC 2.4.1.110 tRNA-queuosine α-mannosyltransferase (1 June 2022)
*EC 2.4.1.221 peptide-O-fucosyltransferase (1 June 2022)
*EC 2.4.1.222 O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase (1 June 2022)
EC 2.4.1.389 solabiose phosphorylase (1 June 2022)
EC 2.4.1.390 4,3-α-glucanotransferase (12 January 2023)
EC 2.4.1.391 β-1,2-glucosyltransferase (12 January 2023)
EC 2.4.1.392 3-O-β-D-glucopyranosyl-β-D-glucuronide phosphorylase (12 January 2023)
EC 2.5.1.4 transferred now EC 4.4.1.42 (12 January 2023)
EC 2.4.3.1 β-galactoside α-(2,6)-sialyltransferase (8 April 2022)
EC 2.4.3.2 β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminide α-2,3-sialyltransferase (8 April 2022)
EC 2.4.3.3 α-N-acetylgalactosaminide α-2,6-sialyltransferase (8 April 2022)
EC 2.4.3.4 β-galactoside α-2,3-sialyltransferase (8 April 2022)
EC 2.4.3.5 galactosyldiacylglycerol α-2,3-sialyltransferase (8 April 2022)
EC 2.4.3.6 N-acetyllactosaminide α-2,3-sialyltransferase (8 April 2022)
EC 2.4.3.7 α-N-acetylneuraminyl-2,3-β-galactosyl-1,3-N-acetylgalactosaminide 6-α-sialyltransferase (8 April 2022)
EC 2.4.3.8 α-N-acetylneuraminate α-2,8-sialyltransferase (8 April 2022)
EC 2.4.3.9 lactosylceramide α-2,3-sialyltransferase (8 April 2022)
EC 2.4.3.10 N-acetylglucosaminide α-(2,6)-sialyltransferase (8 April 2022)
EC 2.4.99.23 lipopolysaccharide heptosyltransferase I (1 June 2022)
EC 2.4.99.24 lipopolysaccharide heptosyltransferase II (1 June 2022)
EC 2.4.99.25 lipopolysaccharide heptosyltransferase III (1 June 2022)
EC 2.4.99.1 transferred, now EC 2.4.3.1 (8 April 2022)
EC 2.4.99.2 transferred, now EC 2.4.3.2 (8 April 2022)
EC 2.4.99.3 transferred, now EC 2.4.3.3 (8 April 2022)
EC 2.4.99.4 transferred, now EC 2.4.3.4 (8 April 2022)
EC 2.4.99.5 transferred, now EC 2.4.3.5 (8 April 2022)
EC 2.4.99.6 transferred, now EC 2.4.3.6 (8 April 2022)
EC 2.4.99.7 transferred, now EC 2.4.3.7 (8 April 2022)
EC 2.4.99.8 transferred, now EC 2.4.3.8 (8 April 2022)
EC 2.4.99.9 transferred, now EC 2.4.3.9 (8 April 2022)
EC 2.4.99.10 transferred, now EC 2.4.3.6 (8 April 2022)
EC 2.4.99.22 transferred, now EC 2.4.3.10 (8 April 2022)
EC 2.5.1.4 transferred now EC 4.4.1.42 (12 January 2023)
EC 2.5.1.155 phosphoglycerol geranylfarnesyltransferase (1 June 2022)
EC 2.5.1.156 geranylfarnesylglycerol-phosphate geranylfarnesyltransferase (1 June 2022)
EC 2.6.1.8 deleted (12 January 2023)
*EC 2.6.1.85 aminodeoxychorismate synthase (8 April 2022)
EC 2.6.1.124 [amino-group carrier protein]-γ-(L-ornithyl)-L-glutamate aminotransferase (1 June 2022)
EC 2.7.1.236 NAD+ 3'-kinase (8 April 2022)
EC 2.7.1.237 GTP-dependent dephospho-CoA kinase (1 June 2022)
EC 2.7.1.238 phenol phosphorylase (1 June 2022)
EC 2.7.1.239 α-D-ribose-1-phosphate 5-kinase (ATP) (12 January 2023)
EC 2.7.2.19 [amino-group carrier protein]-L-glutamate 6-kinase (1 June 2022)
*EC 2.7.4.21 inositol-hexakisphosphate 5-kinase (1 June 2022)
*EC 2.7.4.24 diphosphoinositol-pentakisphosphate 1-kinase (1 June 2022)
EC 2.7.7.108 protein adenylyltransferase (6 July 2022)
*EC 2.7.8.7 holo-[acyl-carrier-protein] synthase (8 April 2022)
EC 2.7.8.48 ceramide phosphoethanolamine synthase (12 January 2023)
*EC 2.7.11.11 cAMP-dependent protein kinase (1 June 2022)
EC 2.7.11.34 NEK6-subfamily protein kinase (1 June 2022)
*EC 2.8.3.18 succinyl-CoA:acetate CoA-transferase (8 April 2022)
EC 2.8.3.27 propanoyl-CoA:succinate CoA transferase (8 April 2022)
EC 2.8.3.28 phenylsuccinyl-CoA transferase (8 April 2022)
EC 3.1.1.119 transferred, now EC 3.2.1.217 exo-acting protein-α-N-acetylgalactosaminidase (8 April 2022)
EC 3.1.1.120 L-fucono-1,5-lactonase (12 January 2023)
EC 3.1.3.81 transferred now EC 3.6.1.75 (6 July 2022)
EC 3.1.3.109 ribulose-1,5-bisphosphate 5-phosphatase (12 January 2023)
*EC 3.2.1.62 glycosylceramidase (8 April 2022)
*EC 3.2.1.108 lactase (8 April 2022)
EC 3.2.1.216 kojibiose hydrolase (8 April 2022)
EC 3.2.1.217 exo-acting protein-α-N-acetylgalactosaminidasee (8 April 2022)
EC 3.2.1.218 α-3'-ketoglucosidase (12 January 2023)
EC 3.2.1.219 palatinase (12 January 2023)
EC 3.3.1.1 transferred (1 June 2022)
EC 3.3.1.2 transferred (1 June 2022)
*EC 3.4.21.109 matriptase (1 June 2022)
EC 3.4.21.122 transmembrane protease serine 2 (1 June 2022)
EC 3.5.1.61 transferred now EC 4.3.3.8 (12 January 2023)
*EC 3.5.4.25 GTP cyclohydrolase II (8 April 2022)
EC 3.6.1.75 diacylglycerol diphosphate phosphatase (6 July 2022)
EC 3.6.1.76 prenyl-diphosphate phosphatase (12 January 2023)
EC 3.13.1.8 transferred (1 June 2022)
EC 3.13 Acting on carbon-sulfur bonds (1 June 2022)
EC 3.13.2 Thioether and trialkylsulfonium hydrolases (1 June 2022)
EC 3.13.2.1 adenosylhomocysteinase (1 June 2022)
EC 3.13.2.2 transferred now EC 4.4.1.42 (12 January 2023)
EC 3.13.2.3 (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming) (1 June 2022)
EC 4.1.1.122 L-cysteate decarboxylase (1 June 2022)
EC 4.1.1.123 phenyl-phosphate phosphatase/carboxylase (1 June 2022)
*EC 4.1.3.27 anthranilate synthase (12 January 2023)
EC 4.1.99.27 cyclopenase (12 January 2023)
*EC 4.2.1.74 medium-chain-enoyl-CoA hydratase (1 June 2022)
EC 4.2.1.180 (E)-benzylidenesuccinyl-CoA hydratase (8 April 2022)
EC 4.2.2.28 α-L-rhamnosyl-(1→4)-β-D-glucuronate lyase (12 January 2023)
EC 4.2.3.206 (–)-cyatha-3,12-diene synthase (12 January 2023)
EC 4.2.3.207 neoverrucosan-5β-ol synthase (12 January 2023)
EC 4.2.3.208 verrucosan-2β-ol synthase (12 January 2023)
EC 4.2.3.209 (R)-axinyssene synthase
EC 4.2.3.210 lydicene synthase (12 January 2023)
EC 4.2.3.211 (+)-exo-β-bergamotene synthase (12 January 2023)
EC 4.3.2.11 (3R)-3-[(carboxylmethyl)amino]fatty acid synthase (6 July 2022)
EC 4.3.3.8 mimosinase (12 January 2023)
EC 4.4.1.42 S-adenosyl-L-methionine lyase (12 January 2023)
EC 4.4.1.43 canavanine-γ-lyase (12 January 2023)
EC 4.6.1.26 uridylate cyclase (1 June 2022)
EC 4.8.1.5 thiohydroximate-O-sulfate sulfate/sulfur-lyase (nitrile-forming) (12 January 2023)
EC 4.8.1.6 N-(sulfonatooxy)alkenimidothioic acid sulfate-lyase (epithionitrile-forming) (12 January 2023)
EC 4.8.1.7 phenyl-N-(sulfonatooxy)methanimidothioate sulfolyase (12 January 2023)
EC 4.8.1.8 N-(sulfonatooxy)prop-2-enimidothioate sulfolyase (12 January 2023)
*EC 5.3.1.4 L-arabinose isomerase (8 April 2022)
*EC 5.3.1.5 xylose isomerase (8 April 2022)
*EC 5.3.1.31 sulfoquinovose isomerase (1 June 2022)
EC 5.3.1.37 4-deoxy-4-sulfo-D-erythrose isomerase (1 June 2022)
EC 5.3.3.24 neopinone isomerase (12 January 2023)
EC 6.2.1.75 indoleacetate—CoA ligase (8 April 2022)
EC 6.2.1.76 malonate–CoA ligase (6 July 2022)
EC 7.1.1.12 succinate dehydrogenase (electrogenic, proton-motive force generating) (1 June 2022)
EC 7.1.3.2 transferred now EC 7.2.3.1
EC 7.2 Catalysing the translocation of inorganic cations (12 January 2023)
EC 7.2.3 Linked to the hydrolysis of diphosphate (12 January 2023)
EC 7.2.3.1 Na+-exporting diphosphatase (12 January 2023)